Publications by authors named "Michele Casale"
Article Synopsis
- HIV-HCV co-infected patients, once considered difficult to treat, showed high success rates (98.4% SVR12) with direct-acting antivirals (DAAs) for HCV treatment.
- The study included 201 patients, mostly males with a median age of 54, and reported minimal side effects like pruritus, headache, and fatigue.
- Six months after DAA treatment, there was a notable increase in CD4+ and CD8+ cell counts, particularly in patients who started with low CD4+ levels.
Background: Natural killer cells are involved in the complex mechanisms underlying autoimmune diseases but few studies have investigated their role in autoimmune hepatitis. Killer immunoglobulin-like receptors are key regulators of natural killer cell-mediated immune responses.
Methods And Findings: KIR gene frequencies, KIR haplotypes, KIR ligands and combinations of KIRs and their HLA Class I ligands were investigated in 114 patients diagnosed with type 1 autoimmune hepatitis and compared with a group of 221 healthy controls.