Publications by authors named "Michele Caneppele"
Ductal carcinoma in situ (DCIS) is widely accepted as a precursor of invasive ductal carcinoma (IDC). Lobular carcinoma in situ (LCIS) is considered a risk factor for invasive lobular carcinoma (ILC), and it is unclear whether LCIS is also a precursor. Therefore, it would be expected that similar risk factors predispose to both DCIS and IDC, but not necessarily LCIS and ILC.
View Article and Find Full Text PDFBackground: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.
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- * Research pooled data from over 6,000 ILC and LCIS cases and identified a specific SNP (rs11977670 at 7q34) that significantly predisposes to ILC.
- * The study highlights 56 polymorphisms associated with ILC and 15 with LCIS, showing that while many ER+ cancer loci relate to ILC, there are differences in susceptibility between ILC and ductal cancers (IDC).