Publications by authors named "Michele Averna"
Deficiencies in fragile X mental retardation protein (FMRP) are the most common cause of inherited intellectual disability, fragile X syndrome (FXS), with symptoms manifesting during infancy and early childhood. Using a mouse model for FXS, we found that Fmrp regulates the positioning of neurons in the cortical plate during embryonic development, affecting their multipolar-to-bipolar transition (MBT). We identified N-cadherin, which is crucial for MBT, as an Fmrp-regulated target in embryonic brain.
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- FMRP is crucial in the brain but also shows potential roles in other organs, including cancer, with its overexpression linked to increased tumor aggressiveness.
- A correlation has been found between FMRP and indicators of aggressive breast cancer, particularly in triple negative types, suggesting a significant impact on cancer prognosis.
- FMRP regulates cancer-related processes by binding to mRNAs involved in epithelial mesenchymal transition (EMT) and invasion, influencing tumor spread and aggressiveness.