Publications by authors named "Michela Gottardi Zamperla"
Correction: Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID‑19 infection: insights from a genome‑wide DNA methylation study.
Luciano Calzari Davide Fernando Dragani Lucia Zanotti Elvira Inglese Romano Danesi Michela Gottardi Zamperla
Clin Epigenetics
November 2024
The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores the evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particularly in DNA methylation patterns, with potential long-term consequences for individuals' health and aging trajectories. The review discusses the potential of DNA methylation-based biomarkers, such as epigenetic clocks, to identify individuals at risk for accelerated aging and tailor personalized interventions.
View Article and Find Full Text PDFEpigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study.
Luciano Calzari Davide Fernando Dragani Lucia Zanotti Elvira Inglese Romano Danesi Michela Gottardi Zamperla
Clin Epigenetics
August 2024
Article Synopsis
- The study investigates the epigenetic changes that occur in patients 6 months after COVID-19 infection, focusing on long-COVID symptoms like fatigue and neurological issues, which may be linked to these changes.
- Researchers analyzed DNA methylation patterns in 96 post-COVID patients versus 191 healthy controls, discovering significant differences associated with genes related to metabolism and immune response.
- Findings indicate potential aging acceleration and dysregulated pathways that could contribute to the symptoms of long-COVID, highlighting the need for further exploration of these epigenetic effects.
Article Synopsis
- HDAC6 is a key player in gene regulation and chromatin dynamics, making it an important focus in cancer research, particularly regarding its role in the stabilization of the P300 protein.* -
- Inactivating HDAC6 using an inhibitor or gene editing techniques results in increased chromatin accessibility and changes in gene expression related to cancer cell behaviors like proliferation and migration.* -
- The study suggests that instead of targeting HDAC6 directly, future cancer therapies could focus on its interaction with P300, highlighting new pathways for targeted treatment based on epigenetic changes.*
Article Synopsis
- SARS-CoV-2 leads to COVID-19, which can cause severe health issues like respiratory problems and even death in about 2.15% of infected individuals.
- Survivors often experience persistent post-COVID-19 syndrome (PPCS) with symptoms such as fatigue, memory loss, and trouble concentrating.
- A study of 117 post-COVID-19 survivors found a significant increase in biological age and telomere shortening compared to 144 COVID-19-free individuals, suggesting possible epigenetic changes, especially in younger patients.