Quality of life in stable schizophrenia: the relative contributions of disorganization and cognitive dysfunction.

Objective: The purpose of this study was to examine the relative contributions of disorganization and cognitive dysfunction to quality of life (QOL) in patients with stable schizophrenia.

Methods: A total of 276 consecutive outpatients with stable schizophrenia were enrolled in a cross-sectional study. We performed a mediation analysis to assess the specific effect of disorganization on QOL, as assessed by the Heinrichs-Carpenter Quality of Life Scale (QLS), and the possible mediating role of cognitive dysfunction.

[Competitive employment in schizophrenia: clinical and neuropsychological correlates and quality of life].

Aim: To investigate the relationships among psychopatology, cognitive functioning, quality of life and competitive employment in patients with stable schizophrenia.

Materials And Methods: We recruited 143 consecutive outpatients with stable schizophrenia, divided into 2 groups (unemployed and competitive employed subjects). A clinical and a neuropsychological assessments were performed.

Cognitive function and competitive employment in schizophrenia: relative contribution of insight and psychopathology.

Purpose: This study investigated the relationships among insight, psychopathology, cognitive function, and competitive employment in order to determine whether insight and/or psychopathology carried the influence of cognitive function to competitive employment.

Methods: We recruited 253 outpatients with stable schizophrenia and we further divided our sample into two groups of patients (unemployed and competitive employment subjects). Clinical and neuropsychological assessments were performed.

Quality of life and psychopathology during the course of schizophrenia.

Objective: This study evaluated a population of outpatients with stable schizophrenia to analyze if relationships between patterns of symptomatology and quality of life (QOL) change during the time course of illness.

Methods: We recruited 168 outpatients with stable schizophrenia, and we further divided our sample into 3 groups of patients (72 months of illness). Psychiatric assessment included the Quality of Life Scale, the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, and the Clinical Global Impression-Severity Scale.

Relative contribution of antipsychotics, negative symptoms and executive functions to social functioning in stable schizophrenia.

The purpose of this study was to examine the relative contributions of antipsychotic medication, negative symptoms and executive functions to impairment in social functioning in a sample of outpatients with stable schizophrenia. One-hundred and sixty-eight consecutive outpatients with stable schizophrenia were enrolled in a cross-sectional study. We performed a path analysis using multiple regression technique in order to assess the specific effect of antipsychotic type (first-generation antipsychotics versus second-generation antipsychotics) on social functioning and the possible mediating role of executive functions and negative symptoms.