A Translational Approach to Standardization of Machine Perfusion Adoption in Ex Vivo Liver Resection.

Background: Hepatic resection represents the best treatment for primary and metastatic liver tumors but is not always feasible. In early 1980, Piclmayr described a complex liver resection technique, termed "ex vivo liver resection," for the treatment of locally advanced tumors not conventionally resectable. The authors approached this technique with translational research in a preclinical setting and then similarly reproduced it in human patients.

Prognostic role of BAP-1 and PBRM-1 expression in intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) has universally poor outcome, mainly due to its late clinical presentation. Identification of specific biomarkers and development of effective treatment are still urgently required. Mutations in PBRM-1 and BAP-1 genes, and the expression of S100P have been related to survival in ICC.

Salvage liver transplantation after laparoscopic resection for hepatocellular carcinoma: a multicenter experience.

Liver transplantation is the ideal treatment for patients affected by early stage hepatocellular carcinoma and chronic liver disease. Considering organs shortage, alternative treatments have to be adopted to minimize the waitlist drop-out, and in case of recurrence within the accepted criteria, salvage transplantation can be considered. Surgical resection is one of the most effective treatments, with the possibility of oncological radicality and pathological analysis of the specimen.

[Treatment of microcarcinoma and papillary carcinoma of the thyroid].

Aim Of The Study: Of our is to demonstrate that total thyroidectomy with lymphadenectomy of the six level is effective in papillary thyroid carcinomas than for microcarcinoma, according to recent acquisitions on the biological behavior of some microcarcinoma.

Materials And Methods: Ours is a retrospective study based on analysis of the process of therapy in 2849 patients undergoing total thyroidectomy, performed from January 1985 to January 2008 by our group at the U.O.

[Parathyroid cyst. Case report].

Parathyroid cysts (PCS) are rare, and less than 300 cases have been reported in literature till now. They occur in most cases as a swelling at the lower third of the neck or are identified by means of diagnostic tests performed for other neck diseases. They are rarely symptomatic.

[Total thyroidectomy vs subtotal thyroidectomy for plurinodular goiter. Analysis 1517 cases].

Aim Of The Study: The surgical treatment of benign thyroid diseases is still controversial, as there is a tendency by some Authors toward a more conservative treatments and wider treatments by others.

Objective: To claim and demonstrate that total thyroidectomy is the best and effective surgical therapy in benign thyroid diseases.

Materials And Methods: Retrospective study based on an analysis of 2136 patients with benign thyroid diseases of the thyroid, observed from January 1985 to July 2008 in the Operative Unit of Surgical Clinic of the Ospedale Vittorio Emanuele of Catania.

[The use of laparoscopy for diagnosis and stadiation of the lymphomas].

Aim: To evaluate feasibility, safety and effectiveness of laparoscopic biopsies in the diagnosis and stadiation of intraabdominal lymphadenopathy.

Material Of Study: From January 2005 to December 2006 12 patients (5 males, 7 females, age 31-54, average 43) with intra-abdominal lymphadenopathy were admitted to our institution (V Chirurgia Generale Ospedale Ferrarotto Catania) to perform laparoscopic biopsies. Indication to treatment was primary diagnosis in ten patients and restaging in two cases.

[Pelvic splenomegaly. Ptosic, migrant or accessory spleen?].

A wandering or ectopic spleen is a rare condition in which the spleen is not located in the left upper quadrant but is found lower in the abdomen or in the pelvic region caused by improper fixation of the ligamentous attachments. Laxity of the peritoneal attachments of the spleen results in splenic hyper mobility, known as wandering spleen. Congenital and acquired causes have been advocated to explain its onset.

[New trends in the treatment of venous leg ulcer. Personal experience].

Venous leg ulcer is the most frequent cause of trophic lesions of the limbs in patients with chronic venous insufficiency. Appropriate management of cutaneous vascular lesions is based on systemic, vascular and local assessment. The Authors used a protease-modulating matrix in 126 patients suffering from venous leg ulcers with wound granulation: 81 (64.