Rationalizing the Design of Hyaluronic Acid-Decorated Liposomes for Targeting Epidermal Layers: A Combination of Molecular Dynamics and Experimental Evidence.

This work provides information on the features of low molecular weight hyaluronic acid (HA)-decorated liposomes to target resveratrol (RSV) in the skin. Deformable liposomes were made of soy-phosphatidylcholine with Tween 80 as the fluidizing agent. For HA conjugation, three different phosphoethanolamines were tested: 1,2-dipalmitoyl--glycero-3-phosphoethanolamine (DPPE), 1,2-dimyristoyl--glycero-3-phosphoethanolamine (DMPE), and 1,2-dioleoyl--glycero-3-phosphoethanolamine (DOPE).