Detecting head and neck squamous carcinoma using a portable handheld electronic nose.

Introduction: Detecting volatile organic compounds in exhaled breath enables the diagnosis of cancer. We investigated whether a handheld version of an electronic nose is able to discriminate between patients with head and neck squamous cell cancer (HNSCC) and healthy controls.

Methods: Ninety-one patients with HNSCC and 72 controls exhaled through an e-nose.

Validation of the Dutch Version of the M.D. Anderson Dysphagia Inventory for Neurogenic Patients.

Background/aim: The aim of this study was to validate the Dutch-language version of the M.D. Anderson Dysphagia Inventory (MDADI) for patients with neurogenic oropharyngeal dysphagia (OD).

Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study.

Background: The aim of this feasibility study was to assess the diagnostic performance of an electronic nose (e-nose) as a noninvasive diagnostic tool in detecting locoregional recurrent and/or second (or third) primary head and neck squamous cell carcinoma (HNSCC) after curative treatment.

Methods: Using an e-nose (Aeonose, The eNose Company, Zutphen, The Netherlands), breath samples were collected from patients after curative treatment of an HNSCC with a locoregional recurrence or second (or third) primary tumor (N = 20) and from patients without evidence of recurrent disease (N = 20). Analyses were performed utilizing artificial neural networking based on patterns of volatile organic compounds.

Training and Validating a Portable Electronic Nose for Lung Cancer Screening.

Introduction: Profiling volatile organic compounds in exhaled breath enables the diagnosis of several types of cancer. In this study we investigated whether a portable point-of-care version of an electronic nose (e-nose) (Aeonose, [eNose Company, Zutphen, the Netherlands]) is able to discriminate between patients with lung cancer and healthy controls on the basis of their volatile organic compound pattern.

Methods: In this study, we used five e-nose devices to collect breath samples from patients with lung cancer and healthy controls.

Differentiating head and neck carcinoma from lung carcinoma with an electronic nose: a proof of concept study.

Disease specific patterns of volatile organic compounds can be detected in exhaled breath using an electronic nose (e-nose). The aim of this study is to explore whether an e-nose can differentiate between head and neck, and lung carcinoma. Eighty-seven patients received an e-nose measurement before any oncologic treatment.

Observers' Agreement on Measurements in Fiberoptic Endoscopic Evaluation of Swallowing.

This study analyzed the effect that dysphagia etiology, different observers, and bolus consistency might have on the level of agreement for measurements in FEES images reached by independent versus consensus panel rating. Sixty patients were included and divided into two groups according to dysphagia etiology: neurological or head and neck oncological. All patients underwent standardized FEES examination using thin and thick liquid consistencies.

Lung Function Testing and Dopaminergic Medication in Parkinson's Disease Patients With and Without Dysphagia.

Background: Swallowing function in individuals with Parkinson's disease (PD) can be negatively affected by dopaminergic medication with associated inhibition of brainstem reflexes. Three different "swallowing-safety" profiles of PD patients were previously observed, classified according to swallowing safety and levodopa.

Methods: Here, we investigated the effects of l-dopa on pulmonary function tests (PFTs) on 26 individuals with PD from the three different swallowing-safety profiles.

Voice- and swallow-related quality of life in idiopathic Parkinson's disease.

Objectives/hypothesis: This study explores whether changes in voice- and swallow-related QoL are associated with progression of idiopathic Parkinson's disease (IPD). Furthermore, it examines the relationship between patients' perception of both voice and swallowing disorders in IPD.

Study Design: Prospective clinical study, quality of life (QoL).