Publications by authors named "Michel de Pontville"
Article Synopsis
- A 20-year-old man with papillary thyroid cancer underwent a fourth round of radioiodine treatment for lung metastases that showed uptake in his body after therapy.
- A follow-up scan revealed that there was unexpected radioiodine uptake on his left lower leg, which raised concerns about potential skin contamination.
- Upon examination, it was determined that the uptake was linked to a scab from a recent fall rather than skin metastasis, and further imaging confirmed it wasn’t related to any bone issues.
Article Synopsis
- The phase III KEYNOTE-913 study focused on assessing the effectiveness and safety of pembrolizumab as a first-line treatment for advanced Merkel cell carcinoma (MCC).
- Results indicated a 49% objective response rate among the 55 patients treated, with a median duration of response of 39.8 months and median overall survival of 24.3 months.
- The treatment showed manageable side effects, with 69% of patients experiencing any grade adverse events, but only 24% facing severe issues, highlighting pembrolizumab's potential in this patient group.
Background: Basal cell carcinoma (BCC) is the most common human malignancy. In most cases, BCC has slow progression and can be definitively cured by surgery or radiotherapy. However, in rare cases, it can become locally advanced or, even more rarely, metastatic.
View Article and Find Full Text PDFAim: To perform a comprehensive analysis of discordances between contrast-enhanced CT (ceCT) and F-FDG PET/CT in the evaluation of the extra-cerebral treatment monitoring in patients with stage IV melanoma.
Materials And Methods: We conducted a retrospective monocentric observational study over a 3-year period in patients referred for F-FDG PET/CT and ceCT in the framework of therapy monitoring of immune checkpoint (ICIs) as of January 2017. Imaging reports were analyzed by two physicians in consensus.
Aim: To evaluate the use of digital F-FDG PET/CT with small-voxels reconstruction for detecting in-transit metastases in melanoma patients with primary lesion located on the upper or lower limbs, in comparison with standard reconstruction and European Association of Nuclear Medicine Research limited (EARL)-compliant reconstruction mimicking former generation PET systems.
Methods: Forty-six PET examinations acquired in list mode on a Vereos digital PET/CT system were reconstructed with (1) the standard reconstruction [2 iterations, 10 subsets (2i10s), point-spread function (PSF) modelling and time-of-flight enabled, no post-filtering and voxel size of 2 mm], (2) a small-voxel reconstruction using 1 mm voxels otherwise using the same parameters, (3) an EARL-compliant reconstruction mimicking a former generation system. Comparison of results across these reconstructions was made for a blind randomized review using a 3-point scale for the presence of in-transit metastases and image quality as well as for tumour-to-background (T/B) ratios and noise level in reference organs.