Efficacy and safety of a new oral saliva equivalent in the management of xerostomia: a national, multicenter, randomized study.

Objective And Study Design: The clinical efficacy, safety, and acceptability of a new oral saliva equivalent (Novasial) administered four times daily in the treatment of xerostomia in various medical conditions was compared with that of oxygenated glycerol triester oral spray (Aequasyal) and a moisturizing spray (Biotene) in a 2-week, multicenter, randomized, crossover study. Assessment included patient-based evaluation of mouth dryness score (primary endpoint) with a visual analog scale (VAS), blinded assessment of the oral tissue condition by a four-point ordinal scale, and patient-based assessment of tolerability and acceptability.

Results: At day 14, Novasial decreased oral mouth dryness by 19.

Effect of influenza vaccination of nursing home staff on mortality of residents: a cluster-randomized trial.

Objectives: To evaluate the effect of staff influenza vaccination on all-cause mortality in nursing home residents.

Design: Pair-matched cluster-randomized trial.

Setting: Forty nursing homes matched for size, staff vaccination coverage during the previous season, and resident disability index.

Management of xerostomia in older patients : a randomised controlled trial evaluating the efficacy of a new oral lubricant solution.

Background: Xerostomia is a subjective sensation of mouth dryness that may frequently occur in older patients.

Objective: To compare the clinical efficacy and acceptability of a new oxygenated glycerol triester (OGT) oral spray taken five times daily with that of a commercially available saliva substitute Saliveze in the treatment of xerostomia.

Methods: Forty-one institutionalised patients (28 women, 13 men; mean age 84 +/- 7 years) were randomly assigned to receive either OGT or Saliveze in a 2-week, randomised, parallel-group study.