The bioavailability of bromazepam, omeprazole and paracetamol given by nasogastric feeding tube.

Aims: To characterize and compare the pharmacokinetic profiles of bromazepam, omeprazole and paracetamol when administered by the oral and nasogastric routes to the same healthy cohort of volunteers.

Methods: In a prospective, monocentric, randomized crossover study, eight healthy volunteers received the three drugs by the oral (OR) and nasogastric routes (NT). Sequential plasma samples were analyzed by high-performance liquid chromatography-UV, pharmacokinetic parameters (Cmax, AUC(0-infinity), t(1/2), k(e), tmax) were compared statistically, and Cmax, AUC(0-infinity) and t(max) were analyzed for bioequivalence.

Panel 2.8: water, sanitation, food safety, and environmental health.

This is a summary of the presentations and discussion by the panel that addressed issues with Water, Sanitation, Food Safety, and Environmental Health during the Conference, Health Aspects of the Tsunami Disaster in Asia, convened by the World Health Organization (WHO) in Phuket, Thailand, 04-06 May 2005. The topics discussed included issues related to water, sanitation, food safety, and environmental health as pertain to the responses to the damage created by the Tsunami. It is presented in the following major sections: (1) needs assessments; (2) institutional capacity and coordination; (3) what was done well, and what could have been done better?; and (4) capacity building and preparedness.

[Thoracic surgery and underfeeding scientific evidences, diagnosis and treatment].

Underfeeding causes a significant increase of postoperative complications, particularly respiratory and infectious complications. Thoracic surgery is frequently required in patients suffering wasting diseases (cancer, COPD, cystic fibrosis), which increase the risk of malnutrition. The most important risk factors are preoperative hypoalbuminemia and BMI < 20.

Biological effects of a dietary omega-3 polyunsaturated fatty acids supplementation in cystic fibrosis patients: a randomized, crossover placebo-controlled trial.

Background And Aims: Various anti-inflammatory therapies, including dietary omega-3 polyunsaturated fatty acids (PUFA) supplementation, have been investigated in cystic fibrosis (CF) patients. To further explore this nutritional approach, biological effects of an omega-3 PUFA oral liquid supplementation were measured in 17 CF patients in a double-blind, randomized, crossover without a washout period and placebo-controlled study.

Methods: CF patients (age: 18+/-9 year; weight: 43+/-13 kg) received a liquid dietary supplementation either enriched or not in omega-3 PUFA (390-1170 mg/day according to patient weight) during two 6-month periods.

Polyunsaturated fatty acid deficiency reverses effects of alcohol on mitochondrial energy metabolism.

Background/aims: Polyunsaturated fatty acids (PUFA) deficiency is common in patients with alcoholic liver disease. The suitability of reversing such deficiency remains controversial. The aim was to investigate the role played by PUFA deficiency in the occurrence of alcohol-related mitochondrial dysfunction.

Electrogastrography reveals post-prandial gastric dysmotility in children with cystic fibrosis.

Objectives: Cystic fibrosis patients have a wide spectrum of gastrointestinal disorders. The aim of this study was to investigate the function of gastroenteric neuromusculature and its response to a prokinetic.

Methods: 14 CF children aged 8.

[Anorexia and malnutrition].

Anorexia is a frequent and complex symptom occurring physiologically in older persons and during acute or chronic pathology. It's an adaptable physiological response to stress. It must be respected as such, as long as it's quickly reversible.

Early nutritional intervention in oropharyngeal cancer patients undergoing radiotherapy.

Nutritional interventions are not routine in patients undergoing oropharyngeal radiotherapy. The aim of the present study was to assess the effects of early nutritional intervention. Forty-five outpatients undergoing radiotherapy for oropharyngeal cancer were prospectively managed by nutritionists (intervention group).

Preoperative nutritional support at home in head and neck cancer patients: from nutritional benefits to the prevention of the alcohol withdrawal syndrome.

Purpose Of Review: Preoperative nutritional support in severely malnourished patients decreases complications after major surgery. This review summarizes previous studies on head and neck cancer patients undergoing surgery, and offers recommendations on preoperative nutritional support based on the literature and our experience.

Recent Findings: Head and neck cancer has a large impact on the patient's quality of life and a high mortality rate.