Publications by authors named "Michel Robaszkiewicz"
Background: An accurate assessment of the evolution of GI endoscopy volumes is warranted to identify long-term trends and to help anticipate training, infrastructure and human resource needs. The main objective of this longitudinal study was to evaluate the evolution of GI endoscopy in France.
Methods: This retrospective study consisted of a cross-sectional analysis repeated each year from 2008 to 2018 using data from a national health database related to hospital admissions.
Background: Colorectal cancer (CRC) screening using fecal immunochemical testing (FIT) aims to detect pre-symptomatic colorectal lesions and reduce CRC mortality.
Aims: The objectives of this study were to determine the FIT sensitivity for diagnosis of CRC, the impact of diagnostic circumstances on treatment and survival, and risk factors for interval cancer (IC).
Methods: This population-based study evaluated the 2016-2017 CRC screening campaign in Finistère, France.
Importance: Although treatment and prognosis of synchronous liver metastases from colorectal cancer are relatively well known, a comparative description of the incidence, epidemiological features, and outcomes of synchronous and metachronous liver metastases is lacking. The difference in prognosis between patients with synchronous and metachronous liver metastases is controversial.
Objective: To investigate temporal patterns in the incidence and outcomes of synchronous vs metachronous liver metastases from colorectal cancer.
Background: An increasing proportion of colorectal cancers (CRCs) are detected through screening due to the availability of organised population-based programmes. We aimed to analyse survival probabilities of patients with screen-detected CRC in European countries.
Methods: Data from CRC patients were obtained from 16 population-based cancer registries in nine European countries.
Long-term outcomes and predictors of disabling disease in a population-based cohort of patients with incident Crohn's disease diagnosed between 1994 and 1997.
Clin Res Hepatol Gastroenterol
November 2022
Background: The identification of early prognostic factors during Crohn's disease (CD) remains needed for physician decision-making to minimize structural bowel damage, which this study aimed to assess in a population-based setting.
Methods: All incident cases of CD were prospectively registered from 1994 to 1997 in Brittany, a limited area of France. All charts of patients were reviewed from the diagnosis to the last clinic visit in 2015.
Article Synopsis
- Survival rates for colon cancer patients have improved due to better treatments and the use of multidisciplinary team meetings (MDTm), but the organization of these meetings can still be optimized.
- A study of 1,616 patients diagnosed between 2014 and 2016 found that 20.5% were not presented in MDTm, mainly due to factors like advanced age, poor condition, and superficial tumors.
- Identifying these non-presentation factors can help target improvements in MDTm organization and ensure more comprehensive patient care.
Proportion and stage distribution of screen-detected and non-screen-detected colorectal cancer in nine European countries: an international, population-based study.
Lancet Gastroenterol Hepatol
August 2022
Background: The effects of recently implemented colorectal cancer screening programmes in Europe on colorectal cancer mortality will take several years to be fully known. We aimed to analyse the characteristics and parameters of screening programmes, proportions of colorectal cancers detected through screening, and stage distribution in screen-detected and non-screen-detected colorectal cancers to provide a timely assessment of the potential effects of screening programmes in several European countries.
Methods: We conducted this population-based study in nine European countries for which data on mode of detection were available (Belgium, Denmark, England, France, Italy, Ireland, the Netherlands, Slovenia, and Spain).
Unlabelled: Population-based studies provide the opportunity to assess the real-world applicability of current clinical practices. The present research evaluated the survival outcomes of different therapeutic strategies for colorectal cancer (CRC) with synchronous metastasis (SM). The differential impact of treatment sequence, viz.
View Article and Find Full Text PDFSocial inequalities are an important prognostic factor in cancer survival, but little is known regarding digestive cancers specifically. We aimed to provide in-depth analysis of the contextual social disparities in net survival of patients with digestive cancer in France, using population-based data and relevant modeling. Digestive cancers ( = 54,507) diagnosed between 2006-2009, collected through the French network of cancer registries, were included (end of follow-up 30 June 2013).
View Article and Find Full Text PDFAim: Oncological strategies in the elderly population are often debated. The objective of this study was to investigate the survival rates and prevalence of ostomy in elderly patients operated on for stage III and IV rectal cancers.
Methods: This retrospective multicentric population-based study included 151 patients aged ≥75 years with stage III and IV rectal adenocarcinoma who underwent surgery between 2007 and 2014.
Article Synopsis
- *Countries with established screening programs, like Germany and Austria, saw a significant decrease in CRC incidence, while newer screening programs showed stable or rising incidence rates until implementation.
- *In nations with high screening participation, such as Denmark and the Netherlands, initial increases in incidence were followed by declines, indicating a potential delayed effectiveness of screening strategies.
Purpose: Oncological strategies in the elderly population are debated. The objective of this study was to assess the factors predictive of poor prognosis in elderly patients with stage III colon cancer.
Methods: A retrospective review of demographic, pathologic, treatment, and outcome data from 308 patients with stage III colon adenocarcinoma who had undergone surgery between 2007 and 2014 was conducted.
Article Synopsis
- The study aimed to explore the incidence, outcomes, and predictors of perianal Crohn's disease (PCD) in a specific population in Brittany, France, by tracking patients from 1994 to 2015.
- Out of 272 patients with Crohn's disease, 18.7% had PCD at diagnosis, and over time, 34% developed PCD, with risks of conditions like anal ulceration and fistulizing PCD increasing over the years.
- The findings suggest that PCD is common in Crohn's disease and highlight the importance of targeted treatment strategies for early symptoms to prevent more severe complications like fistulizing disease.
Objective: The aim of this study was to compare quality performance of the first colorectal cancer (CRC) screening campaigns (C) with the OC Sensor® Faecal Immunological Test (FIT) (C7 from 2016 to 2017) and the Hemoccult® guaiac-based test (C1 from 2004 to 2006).
Methods: The participation rate of the eligible population, screening fecal occult blood test (FOBT) performance indices, CRC and adenoma detection rate and time interval between test positivity and colonoscopy were studied.
Results: In C7, 35.
Background: Oesophageal radiofrequency reduces use of proton pump inhibitors (PPIs) in patients with gastro-oesophageal reflux disease responding to PPIs.
Aim: To determine the efficacy of oesophageal radiofrequency in patients with PPI-refractory heartburn.
Methods: A randomised, double-blind, sham-controlled multicentre study was designed to assess the efficacy of oesophageal radiofrequency in PPI non-responding patients with heartburn.
Article Synopsis
- The SARS-CoV-2 pandemic significantly decreased gastrointestinal (GI) endoscopy activity in France, as shown by a comprehensive web-based survey conducted among French gastroenterologists.
- Out of 694 respondents, a staggering 98.7% reported having to cancel procedures due to the pandemic's impact, with a notable percentage involved in managing COVID-19 patients.
- The study reveals concerning health implications, including potential delays in treating gastroenterology patients, particularly those with GI cancers, due to the restricted access to necessary endoscopic procedures.
Aim: We aimed to study the prognostic value of , , mutations and microsatellite stable (MSS)/instable (MSI) in the field of colorectal cancer invading the (ie, pT1 colorectal cancer (CRC)).
Methods: We led a case-control study in tumour samples from 60 patients with pT1 CRC with (20 cases) and without (40 cases) metastatic evolution (5 years of follow-up) which were analysed for , , mutations (Idylla testing and next generation sequencing, NGS) and MSS/MSI status (Idylla testing and expression of mismatch repair (MMR) proteins using immunohistochemistry).
Results: mutations were encountered in 11/20 (55%) cases and 21/40 (52.
Article Synopsis
- Small bowel cancer encompasses various types, and a study in France over the last 20 years aimed to analyze trends in incidence based on histology.
- The study found that overall incidence rates are higher in men (1.46/100,000) compared to women (0.9/100,000), with adenocarcinoma being the most common type (38%) followed by neuroendocrine tumors (35%).
- Incidences of all tumor types, except lymphoma in men, significantly increased over the 20 years, potentially linked to advancements in imaging techniques and the need to explore underlying predisposing factors contributing to these trends.
The therapeutic management of patients with endoscopic resection of colorectal cancer invading the submucosa (i.e. pT1 CRC) depends on the balance between the risk of cancer relapse and the risk of surgery-related morbidity and mortality.
View Article and Find Full Text PDFArticle Synopsis
- This study looks at how doctors can tell if patients with early colorectal cancer (pT1 CRC) need more surgery by checking for cancer risks like lymph node invasion and tumor recurrence.
- Two pathologists reviewed 163 cases from a database in France, looking at specific factors based on guidelines.
- They found that using certain types of tests made it easier for doctors to agree on the risk levels, especially for lymphovascular invasion and tumor budding, which helps decide if additional surgery is necessary.
Background: There is no consensus about the histopathologic methods to detect Helicobacter pylori in gastric biopsies to date. We aimed to question about the value of upfront anti-H. pylori immunohistochemistry in this field.
View Article and Find Full Text PDFRecently, our resequencing of the promoter region of PRSS1 in French Caucasian individuals led to the identification of a functional variant (c.-204C > A) that is in perfect linkage disequilibrium with the "chronic pancreatitis (CP)-protective" PRSS1 c.-408C > T variant.
View Article and Find Full Text PDFBackground And Study Aim: Infectious outbreaks associated with the use of gastrointestinal endoscopes have increased in line with the spread of highly resistant bacteria. The aim of this study was to determine the measures required to improve microbial quality surveillance of gastrointestinal endoscopes.
Methods: We reviewed the results of all microbiological surveillance testing of gastrointestinal endoscopes and automatic endoscope reprocessors (AERs) performed at Brest Teaching Hospital from 1 January 2008 to 1 June 2015.