Effects of Neuroanatomic Structural Distances on Pituitary Function After Stereotactic Radiosurgery: A Multicenter Study.

Background: Delayed hypopituitarism is the most common complication after stereotactic radiosurgery (SRS) for pituitary adenomas.

Objective: To investigate the relationship between neuroanatomic structure distances from the radiation target and anterior pituitary function preservation after SRS through multicenter study.

Methods: We retrospectively reviewed the International Radiosurgery Research Foundation database from January 2002 to December 2021 for adult patients undergoing SRS for pituitary adenomas with >6 months of follow-up.

Dose to neuroanatomical structures surrounding pituitary adenomas and the effect of stereotactic radiosurgery on neuroendocrine function: an international multicenter study.

Objective: Stereotactic radiosurgery (SRS) provides a safe and effective therapeutic modality for patients with pituitary adenomas. The mechanism of delayed endocrine deficits based on targeted radiation to the hypothalamic-pituitary axis remains unclear. Radiation to normal neuroendocrine structures likely plays a role in delayed hypopituitarism after SRS.

Update on primary micronodular bilateral adrenocortical diseases.

Purpose Of Review: Primary micronodular bilateral adrenocortical hyperplasias (MiBAH) are rare challenging diseases. Important progress in understanding its pathophysiology and genetics occurred in the last two decades. We summarize those progress and recent data on investigation and therapy of MiBAH focusing on primary pigmented nodular adrenocortical disease (PPNAD).

Cardiorespiratory and efficiency responses during arm and leg exercises with spontaneously chosen crank and pedal rates.

The aim of this study was to compare the cardiorespiratory and efficiency responses between upper (T(UBE)) and lower (T(LBE)) body exercises at the same relative power outputs and with spontaneously chosen crank (SCCR) or pedal (SCPR) rates. Twelve participants performed exercise bouts set at 20, 40, 60 and 80% of maximal power (MP) separated by passive recovery periods. Oxygen uptake, ventilation, gross and work efficiencies during T(LBE) were significantly (P < 0.