[Tuberculosis of shoulder bone].

We present a case of 39-year old man in whom after one year of corticotherapy due to suspicion of lung sarcoidosis, pathologic changes in left shoulder bone were diagnosed. Bone biopsy was carried out with subsequent development of skin fistula with matter drainage. Based on histological examination of bone specimen and bacteriological tests - tuberculosis was diagnosed.

[Granuloma of epididymis of patient treated with intravesical BCG therapy--complication of BCG therapy or tuberculosis?].

We present a case of 72-year old man treated from 2007 for superficial bladder carcinoma. Patient had undergone surgical intervention for transitional cell carcinoma of the bladder, followed by BCG therapy. Two years later enlarged right testis and epididymis was observed.

[Interferon-gamma assays T-SPOT.TB for the diagnosis of latent tuberculosis infection].

Introduction: The diagnosis of latent tuberculosis infection (LTBI) is currently based on the century-old tuberculin skin test (TST). However a positive reaction can result from infection by Mycobacterium tuberculosis, BCG vaccination or cross-reaction with nontuberculous mycobacteria. T-SPOT.

Angiogenic activity of sera from pulmonary tuberculosis patients in relation to IL-12p40 and TNFα serum levels.

The role of angiogenesis in the pathogenesis of tuberculosis (TB) is not clear. The aim of this study was to examine the effect of sera from TB patients on angiogenesis induced by different subsets of normal human mononuclear cells (MNC) in relation to IL-12p40 and TNFα serum levels. Serum samples from 36 pulmonary TB patients and from 22 healthy volunteers were evaluated.

Heterogeneity of antibody response to myobacterial antigens in different clinical manifestations of pulmonary tuberculosis.

Different clinical outcomes of tuberculosis can be related to the balance between cell-mediated and humoral immunity. In this prospective study we examined the humoral immune responses to recombinant and native mycobacterial antigens in relation to clinical presentations of pulmonary TB. Two hundred and fifteen serum samples were examined including: non-cavitary (n=120), cavitary (n=65), caseous pneumonia (n=12), and disseminated TB (n=18).

[Humoral immune response against mycobacterial antigens in patients with tuberculosis and mycobacterial infections other than tuberculosis].

The aim of the study was to compare humoral immune response against various mycobacterial antigens in TB and MOTT vs healthy control group. 350 serum samples from TB patients, 20 samples from MOTT patients and 58 samples from healthy donors were examined. ELISA detecting IgG, IgA and IgM against antigens: 38 kDa and 16 kDa, 38kDa and lipoarabinomannan, and A-60 were used.

Diagnostic value of different serological tests for tuberculosis in Poland.

The aim of the study was to test the diagnostic accuracy of several serological assays for the diagnosis of tuberculosis (TB) in the Polish population. ELISA based assays detecting: 38 kDa+LAM - MycoM, MycoA and MycoG, 38 kDa - Pathozyme TB complex, 38 kDa+16 kDa - Pathozyme TB complex plus were used. The humoral immune response was analyzed in a group of 319 TB patients (289 adults and 30 children) and in a control group consisting of 66 sarcoidosis cases, 16 cases of mycobacterial infections other than tuberculosis, 35 lung cancer patients, and 70 healthy volunteers.

[Value of the immunochromatographic assay for detecting IgG antibodies against 38 kDa mycobacterial antigen in diagnosis of tuberculosis].

Despite of a fast development in the techniques of rapid identification of mycobacteria by molecular genetic techniques, serodiagnosis may be of special values as non-expensive, easy to perform method. Several serodiagnostic tests, principally those using immunoenzymatic (ELISA) methodology are available. The goal of our study was to evaluate one step coloured immunochromatographic assay detecting IgG antibodies against antigen 38 kDa (Rapid Test TB).

[Usefulness of measuring serum IGG antibodies against A60 mycobacterial antigen for diagnosis of tuberculosis].

Measurement of antimycobacterial antibody may be used as potential diagnostic tool in tuberculosis. The aim of the study was to evaluate the diagnostic value of serum IgG level against A60 mycobacterial antigen measured by ELISA method. Material consisted of 144 persons divided into 5 groups (76 tuberculosis patients, 20 sarcoidosis patients, 17 lung cancer patients, 8 patients with mycobacterial infections other than tuberculosis and 23 healthy controls).

[Diagnostic value of IgG antibody levels against 38 kDa mycobacterial antigen].

Tuberculosis diagnosis bases on clinical and radiological symptoms and identification of mycobacteria. Accuracy of both methods is limited. Therefore reliable serological test would have considerable advantage.

[Surgical treatment of patients with multi-resistant pulmonary tuberculosis--case reports].

Two patients with multidrug-resistant pulmonary tuberculosis were surgically treated after 3 and 7 years of unsuccessful chemotherapy. There was pneumonectomy in one case and lobectomy with segmentectomy in the second. Pneumonectomy was complicated by bronchopleural fistula.

[Reasons for chronic expectoration--case reports].

To illustrate reasons for chronic culture positive pulmonary tuberculosis 4 patients are presented. In two cases the reasons for treatment failure were on the doctors' side. In one case a doctor used an insufficient number of drugs, in the second case the treatment was too short.

[Reasons for chronic expectoration in patients with pulmonary tuberculosis registered in the Central Tuberculosis Registry].

The aim of the retrospective population-based study was to identify reasons for failure of sputum culture negativity from the 12th month on since the start of chemotherapy of pulmonary tuberculosis (PTB). Medical records of 97 patients with PTB (85 men and 12 women) remaining sputum culture positive for over 12 months, reported to the Central TB Registry (1988-1990), were reviewed. The mean age was 46.

[Treatment of patients for chronic pulmonary tuberculosis with expectoration--selection and tolerance to drugs].

In retrospective analysis of 48 patients with chronic pulmonary tuberculosis we concluded that in spite of increasing drug resistance to first line drugs only 52% chronics received other than first line antituberculous drugs. Our treatment was based on the selection of drugs according to susceptibility tests. 4-6 drugs were used at the beginning of treatment.

[Treatment of patients with chronic pulmonary tuberculosis with expectoration--evaluation of effectiveness].

48 patients with chronic pulmonary tuberculosis (10 women and 38 men) aged between 22 and 87 years were treated. They were sputum culture positive from 1 to 12 years (x = 3.6).

[Reasons for chronic sputum culture positive tuberculosis--evaluation based on personal experience].

It is commonly believed that chronic sputum positivity in treated pulmonary tuberculosis is caused by the patients' noncompliance. We have undertaken retrospective analysis of the records of 59 patients to verify reasons of treatment failure. The group consisted of 12 women and 47 men aged between 22 to 87 (median: 47) who were sputum culture positive from 1 to 12 years (x = 3.

[Tuberculosis of the bones and joints].

The incidence of tuberculosis has increased over the last several years. Bones and joints tuberculosis makes 20% of all extrapulmonary locations of tuberculosis. In Poland this form of tuberculosis is underdiagnosed.

[Incidence of tuberculosis in patients with hematologic malignancies].

The analysis of the incidence of tuberculosis in patients with hematological malignancies was performed in 2,025 patients hospitalized in internal clinic. Only in 42 cases tuberculosis was noticed.

[Studies on the effectiveness of a new model for treating tuberculosis with prolonged administration of isoniazid].

The aim of the study was to determine the therapeutical effectiveness of a new regimen in freshly diagnosed cases of pulmonary tuberculosis. In this model PZA and SM were excluded, but INH administration was prolonged. Instead of INH and RMP a combined drug was given--RIFAMAZIDE (Polfa).