Modified Release Studies on Melatoninergic Fluorinated Phenylalkylamides: Circumventing their Lipophilicity for Oral Administration.

Introduction: In an attempt to circumvent the lipophilicity burden for the oral administration of new potent synthetic melatoninergic fluorine-substituted methoxyphenylalkyl amides, we conducted modified release studies using carefully selected matrix tablets' biopolymeric materials in different ratios.

Methods: In particular, we sought to attain release profiles of these analogues similar to that of the parent compound, the chronobiotic hormone Melatonin (MLT), and also of the commercially available drug, Circadin.

Results: It was found that some of these systems, albeit being more lipophilic than MLT, mimic the release patterns of melatonin and Circadin.