Publications by authors named "Michalis Nikolaou"
Background: Pseudomyxoma peritonei (PMP) is a clinical entity of subtle onset abdominal pain, ascites, and distention associated with characteristic imaging. In most cases, laparoscopic exploration will give the definitive diagnosis and histopathologic verification. However, usually there are difficulties in the diagnosis of this disease.
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- * Results show that CTC positivity at baseline is linked to shorter overall survival rates and predicts early recurrence, but not late recurrence, suggesting its prognostic impact varies over time.
- * Additionally, most patients transitioned from CTC-positive to CTC-negative after chemotherapy treatment, indicating CTC detection can inform potential new treatment strategies.
Objectives: The aim of the study was to characterize and evaluate the presence of DLL3-positive Circulating Tumor Cells (CTCs) in SCLC patients receiving front-line chemotherapy and assess their clinical relevance.
Materials And Methods: Peripheral blood was obtained from treatment-naïve patients with SCLC (n = 108 patients), after one etoposide/platinum cycle (n = 68 patients) and on disease progression (n = 48 patients). Immunofluorescence staining using antibodies against the DLL3, cytokeratins (CK), CD45 and vimentin (Vim) was used for the detection and characterization of CTCs.