Publications by authors named "Michalina S Thiel"
Advancing chimeric antigen receptor (CAR)-engineered T cells for the treatment of solid tumors is a major focus in the field of cellular immunotherapy. Several hurdles have hindered similar CAR T cell clinical responses in solid tumors as seen in hematological malignancies. These challenges include on-target off-tumor toxicities, which have inspired efforts to optimize CARs for improved tumor antigen selectivity and overall safety.
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- Apoptosis is a crucial immune response activated by infection in eukaryotes, playing a significant role in defending against pathogens, but its specific role in arthropod vectors and rickettsiae is not well understood.
- The study revealed that rickettsial infection triggered apoptosis in a tick cell line and other tick species' cell lines, with findings showing that suppressing apoptosis hindered rickettsial infection, while activating it increased early infection stages.
- The research indicates that mitochondrion-dependent apoptosis is vital for rickettsial replication in vector cells, and rickettsiae employ different survival strategies to influence apoptosis, providing insights into how these processes impact pathogen transmission and tick-borne diseases.