Optic pathway glioma and endocrine disorders in patients with and without NF1.

Background: Optic pathway gliomas (OPGs) are classified by anatomic location and the association with neurofibromatosis type 1 (NF1). Children with OPGs face sequelae related to tumor location and treatment modalities. We assessed the prevalence of endocrine dysfunction in children with OPGs and compared outcomes between those with and without NF1.

Which predictors differentiate between obese children and adolescents with cardiometabolic complications and those with metabolically healthy obesity?

Background/aims: Childhood obesity and associated metabolic comorbidities is a major global health concern. Metabolically healthy obesity (MHO) may represent a subgroup of individuals in which excessive body fat accumulation does not lead to adverse metabolic effects. We aimed to determine the prevalence of MHO among obese Israeli children and adolescents and to find predictors for metabolically unhealthy obesity (MUO).

Impact of childhood type 1 diabetes on maternal work-family relations.

Background: The aim of the study was to evaluate work-family conflict (WFC) and work-family facilitation (WFF) of working mothers of children with type 1 diabetes (T1D) compared with those of working mothers of children under follow-up not requiring treatment and of healthy children, and to explore the impact of organizational resources and the characteristics of the child and his disease on this interface.

Methods: The study included 157 working mothers: 50 mothers of children with T1D, 50 mothers of children on medical follow-up without chronic illness and 57 mothers of healthy children. The participants completed validated questionnaires including the WFC scale, WFF scale, organizational resources support scale, life and work satisfaction questionnaire, a background demographic questionnaire and a child health questionnaire.

Growth and pubertal patterns in young survivors of childhood acute lymphoblastic leukemia.

Background: Survivors of acute lymphoblastic leukemia (ALL) may experience endocrine dysfunction. This study evaluated growth and pubertal patterns in survivors of childhood ALL.

Methods: Longitudinal assessment of anthropometric measurements and pubertal status was performed in a retrospective cohort of survivors (n=183).

Do children, adolescents, and young adults with type 1 diabetes have increased prevalence of sleep disorders?

Background: Sleep has been shown to impact glucose regulation, and may be altered in persons with type 1 diabetes (T1D).

Objective: To assess sleep characteristics in T1D patients and the possible association between sleep disturbances and diabetes-related variables.

Subjects And Methods: In a cross-sectional study in 154 young patients with T1D and 154 age-range-matched nondiabetic controls subjective sleep characteristics were assessed using validated questionnaires: Sleep Disturbance Scale for Children (SDSC), Adolescent Sleep-Wake Scale (ASWS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS).