Publications by authors named "Michal Wrobel"

Background: Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA) may affect female reproductive function and embryo transport by influencing uterine contractility through its receptors (LPARs).

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Previously studied classes of pesticides, including organochlorines, organophosphates and pyrethroids disturb the mechanism that causes bovine myometrial contractions. Hence, the aim of this study was to investigate the effects of carbaryl and thiram, which are representative carbamate pesticides commonly used in global agriculture, on the motor and secretory functions of bovine cervixes. Additionally, the impacts of these pesticides on intra- and intercellular signaling in vitro were estimated.

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The aims of this study were to examine the effect of luteotropic and luteolytic factors on the mRNA and protein expression of the coactivators HAT: histone acetyltransferase p300 (P300), cyclic adenosine monophosphate response element-binding protein (CREB), and steroid receptor coactivator-1 (SRC-1) and the corepressor: nuclear receptor corepressor-2 (NCOR-2) in bovine luteal cells on days 6-10 and 16-20. HAT and HDAC activities were also measured. The obtained results showed that luteotropic and luteolytic factors influence changes in the mRNA and protein levels of the coregulators of PGRs.

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Nowadays, an increasing amount of reclaimed asphalt pavement (RAP) is being produced from the reconstruction and/or modernisation of asphalt pavements. It is necessary to recycle the obtained RAP according to principles of sustainable development. Therefore, this work includes the design of asphalt mixtures containing RAP with bio-derived modifier and evaluates their performance properties.

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The Eurasian beaver is currently found in at least 32 European countries, with many of these populations being established in the 1960s. In most European countries, the beaver is under protection, however, when the population is strong, the beaver becomes a game species. In Poland, the beaver is partially protected despite the species having a strong population.

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Here, we report the isolation, whole-genome sequencing, and annotation of four novel Pseudomonas isolates. We also evaluate the biosynthetic potential of each genome.

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This study aimed to investigate the effect of pyrethroid insecticides on the regulation of bovine cervical function. Cervical cells or strips obtained from cows during the periovulation period were treated with cypermethrin and fenvalerate (0.1-10 ng/mL).

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Glyphosate (Gly) and atrazine (Atr) are among the most commonly used herbicides in global agriculture. It was previously shown that both Atr and Gly impair the ovarian and uterine secretion of regulators of myometrial motility (oxytocin (OT) or prostaglandins (PGs)) in cows, and Atr can also decrease the force of contractions in strips from the uterine horn. Hence, the aim of this study was to compare the effects of Atr and Gly on the motor and secretory function of the bovine cervix in vitro as well as receptivity and signal transduction in cervical cell cultures.

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Destructive corrosion processes lead to the loss of primary mechanical properties of metal construction materials, which generates additional costs during their maintenance connected with repairs and protection. The effectiveness of corrosion inhibitors can be determined by using many methods, in particular quantum chemical modeling. The subject of the theoretical analyses presented in this work involves the anticorrosion properties of amines with various chemical structures.

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Data reusability is an important feature of current research, just in every field of science. Modern research in Affective Computing, often rely on datasets containing experiments-originated data such as biosignals, video clips, or images. Moreover, conducting experiments with a vast number of participants to build datasets for Affective Computing research is time-consuming and expensive.

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Brick debris is one of the main construction wastes obtained from demolition of buildings. However, this material can be successfully used in the recycling process. The purpose of the study was to determine the brick dust addition effect on asphalt surface service life.

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Polychlorinated biphenyls (PCBs) are a group of synthetic xenobiotics that have been used in many industrial applications. Currently, PCBs are among the most prominent environmental contaminants. Previously we showed that PCBs impair secretion of prostaglandins (PGs) at the oviduct.

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Compaction index is one of the most important technological parameters during asphalt pavement construction which may be negatively affected by wrong asphalt paving machine set, weather conditions, or the mix temperature. Presented laboratory study analyzes the asphalt mix properties in case of inappropriate compaction. The reference mix was designed for AC 11 S wearing layer (asphalt concrete for wearing layer with maximum grading of 11 mm).

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Zeolite materials are used in the warm mix asphalt technology as an asphalt foaming additive, which partially replaces the filler. This article analyzes the influence of the zeolite and other fillers addition on the properties of mastic asphalt. In the research, 35/50 penetration grade asphalt and three types of fillers were used: lime filler (L), zeolite tuff (clinoptilolite) (C), hydrated lime (H) and their mixed combinations (C:L in 1:1 and 1:3 proportions as well as C:L:H in 2:2:1 ratio).

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The previous studies on asphalt mix and asphalt with waste engine oil addition indicate the possibility of using this type of waste material for the construction of road pavements. The research presented in this paper aimed at the preliminary assessment of possible waste engine oil (WEO) addition to the asphalts foamed with water-soaked zeolites. In this research, synthetic zeolite Na-P1 and natural clinoptilolite were used.

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Introduction: Bladder cancer is one of the most common malignancies worldwide.

Aim: To analyse the influence of restaging transurethral resection of bladder tumour (reTURB) on outcomes in patients treated with BCG immunotherapy.

Material And Methods: We analysed a database of 491 patients who were treated in a Bacillus Calmette-Guérin (BCG) outpatient department between 1998 and 2016.

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Purpose: To evaluate on a large group of patients whether Mantoux tuberculin skin test (TST) result is associated with BCG immunotherapy effectiveness and whether it can predict occurrence of moderate to severe toxicity.

Materials And Methods: We analysed group of 823 patients with intermediate and high risk NMIBCs who were treated with BCG. The study included 412 patients with the history TST and 411 without TST.

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Introduction: The study aimed to analyze the influence of restaging transurethral resection of bladder tumor (reTURB) timing on outcomes in patients receiving Bacillus Calmette-Guerin (BCG) immunotherapy.

Material And Methods: This retrospective study enrolled 491 patients with bladder cancer receiving BCG intravesical therapy between 1998 and 2016. All patients were followed up for at least 12 months and received at least 7 BCG instillations.

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Aldrin, dieldrin, and DDT are chlorinated insecticides that are unintentionally widespread in the environment. It was previously shown that all of the aforementioned compounds increased secretion of ovarian oxytocin (OT), which is a potent uterotonic agent. However, only DDT and its metabolite (DDE) promoted, while aldrin and dieldrin inhibited basal and OT-stimulated myometrial contractions in cows.

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In the first part of this paper a universal fluid velocity based algorithm for simulating hydraulic fracture with leak-off was created for a penny-shaped crack. The power-law rheological model of fluid was assumed and the final scheme was capable of tackling both the viscosity and toughness dominated regimes of crack propagation. The obtained solutions were shown to achieve a high level of accuracy.

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In the first part of this paper, a universal fluid velocity based algorithm for simulating hydraulic fracture with leak-off, previously demonstrated for the PKN and KGD models, is extended to obtain solutions for a penny-shaped crack. The numerical scheme is capable of dealing with both the viscosity and toughness dominated regimes, with the fracture being driven by a power-law fluid. The computational approach utilizes two dependent variables; the fracture aperture and the reduced fluid velocity.

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The effect of atrazine and linuron, the popular and widely used chlorinated herbicides, on both myometrial contractions and secretory functions of bovine uterus and ovaries in vitro, was investigated. The pesticides inhibited (P<0.05) the basal and oxytocin (OT)-stimulated myometrial strips contractions, as well as the effect of OT on secretion of prostaglandins (PGs: PGF2α and PGE2) from endometrium.

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The Thymus genus has a firm position in Mediterranean folk medicine and culinary tradition, and yet certain confusion is observed in its botanical taxonomy. Therefore, chemical analysis of secondary metabolites and selection of reliable chemotaxonomic markers can prove helpful. In this study, the volatile fraction derived from 20 different thyme specimens was analyzed by means of headspace GC with MS detection.

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