Publications by authors named "Michal Syonov"
Aims/hypothesis: A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction of the cerebrovascular endothelium and the subsequent development of associated cognitive impairment. The present study tested the hypothesis that during type 2 diabetes circulating small extracellular vesicles (sEVs) exhibit phenotypic changes that facilitate pathogenic disruption of the vascular barrier.
Methods: sEVs isolated from the plasma of a mouse model of type 2 diabetes and from diabetic human individuals were characterised for their ability to disrupt the endothelial cell (EC) barrier.
Article Synopsis
- - Liver failure can disrupt the Blood CNS Barrier (BCB), leading to damage in the Central Nervous System (CNS), but the exact mechanisms are not yet fully understood.
- - Researchers developed advanced imaging techniques to study the integrity of the BCB, discovering that specific genetic changes in mice lead to BCB breakdown and subsequent brain damage.
- - The study highlights a potential protective role of a molecule called HFE2, which could prevent BCB dysfunction and offers insights into treating conditions like multiple sclerosis related to blood-brain barrier issues.