Publications by authors named "Michal Medini"
Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as colitis, contributing to diarrhoea and perpetuating inflammation. We show that the zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS) ulcerative colitis model.
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- Utilizing endogenous molecules like α1-antitrypsin (AAT) is generally more effective as a therapy than synthetic alternatives, particularly due to its anti-inflammatory and wound-healing properties.
- AAT has been used for decades to treat a rare genetic deficiency and shows promise in reducing tissue damage from conditions such as ischemic heart disease and stroke.
- Current clinical trials are investigating AAT for treating type 1 diabetes, with early results indicating it may enhance insulin production without negative side effects for some patients.