Application of the HPLC-ELSD technique for the determination of major metabolites of ibuprofen and creatinine in human urine.

The report presents robust and high throughput methods, based on liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD), for the simultaneous determination of major metabolites of ibuprofen (IBU), namely 2-hydroxyibuprofen and carboxyibuprofen (method A) as well as creatinine (Crn) (method B) in human urine. The assays primarily involve straightforward sample purification. For both methods, the chromatographic separation of the analytes is achieved within 8 min at room temperature on Poroshell 120 SB-C18 (75 × 4.

Systematic Review of Clinical Practice Guidelines for the Improvement of Medication Adherence.

Background: Poor adherence to medications is a significant problem that leads to increased morbidity, mortality, and health care costs. Recommended approaches to address medication adherence vary, and existing practice guidelines are unclear.

Purpose: This review evaluated clinical practice guidelines designed to help health care providers address patients' medication adherence.

[Prevalence, reasons, and forms of use of legal highs by internet-based survey participants].

Aim: The aim of this study was to assess the prevalence, causes and forms of the use of legal highs in Poland.

Methods: The study was based on an original questionnaire and was carried out through the Internet before banning of the legal highs in Poland.

Results: The study covered 3013 people, aged 24.

Determinants of patient adherence: a review of systematic reviews.

Purpose: A number of potential determinants of medication non-adherence have been described so far. However, the heterogenic quality of existing publications poses the need for the use of a rigorous methodology in building a list of such determinants. The purpose of this study was a systematic review of current research on determinants of patient adherence on the basis of a recently agreed European consensus taxonomy and terminology.

A new taxonomy for describing and defining adherence to medications.

Interest in patient adherence has increased in recent years, with a growing literature that shows the pervasiveness of poor adherence to appropriately prescribed medications. However, four decades of adherence research has not resulted in uniformity in the terminology used to describe deviations from prescribed therapies. The aim of this review was to propose a new taxonomy, in which adherence to medications is conceptualized, based on behavioural and pharmacological science, and which will support quantifiable parameters.