Publications by authors named "Michal Koubek"
Article Synopsis
- The study aimed to assess the occurrence of ocular side effects following the loading phase of brolucizumab therapy in patients with neovascular age-related macular degeneration (nAMD), distinguishing between treatment-naive patients and those switching from another anti-VEGF treatment.
- Conducted as a multicenter, retrospective study across 16 centers in the Czech Republic, it included 1,098 eyes, monitoring both adverse events and changes in visual acuity and retinal thickness over an average follow-up of 120 days.
- Results showed that 3.83% of eyes experienced adverse events, with worse visual acuity outcomes for patients who switched from previous treatments compared to those who were treatment-naive, indicating potential implications for treatment strategies
Article Synopsis
- The study evaluated the effectiveness of aflibercept in treating treatment-naive patients with neovascular age-related macular degeneration (nAMD) by analyzing three types of choroidal neovascular membranes: Type 1 (occult), Type 2 (classic), and Type 4 (minimally classic).
- A total of 135 eyes from 135 patients were studied over 48 weeks, receiving three initial injections every four weeks followed by injections every eight weeks, with measurements of best-corrected visual acuity (BCVA) and central retinal thickness (CRT) taken at multiple follow-up points.
- Results showed an improvement in BCVA and a decrease in CRT for Type
Introduction: Ankyloblepharon filiforme adnatum associated with Hay-Wells syndrome is a rare congenital disease caused by mutations in TP63 gene on the 3q27 chromosome. Here, we report a case of a new-born suffering from this syndrome in whom we detected a mutation c.1709T>C not previously included in the Ensemble database.
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