Background: Compounds of N-alkylated benzamide derivatives have been the subject of investigations in the last few decades from the standpoint of their possible application for scintigraphic detection of melanoma. Positive results have been observed in studies on biodistribution when using animal models and the compound IMBA (N-(2-diethylaminoethyl)-3-iodo-4-metoxybenzamide). The present study presents preliminary results of scintigraphic studies in patients with documented melanoma metastases, who were administered ¹³¹I-IMBA synthesized by modified labelling procedure (electrophilic substitution of radioactive ¹³¹I to metal organic substituent).
View Article and Find Full Text PDFNucl Med Rev Cent East Eur
June 2010
Melanoma malignum belongs to the group of neoplasms with the highest lethality. Due to the continuous increase of incidence in numerous countries, this malignance has become a serious health problem. This highly aggressive neoplasm is a source of metastases to most organs and eo ipso of bad prognosis.
View Article and Find Full Text PDFBackground: Numerous reports indicate that some iodinated compounds of benzamide derivatives display a strong affinity to the cells of melanoma. In the present report, a compound [N-(2-diethylaminoethyl)-3-iodo-4metyoxybenzamide ((131)I-IMBA)] has been prepared by two different labelling methods. Biodistribution of the injected compound was followed in mice with experimentally induced B16 melanoma tumours, and tumour/ tissue ratios were studied as a function of time post administration.
View Article and Find Full Text PDF