Publications by authors named "Michal Hubacek"
Article Synopsis
- Improvement of photosynthesis requires understanding how electrons are distributed under different conditions, which was studied in the engineered cyanobacterium Synechocystis sp. PCC 6803 expressing a gene for an enzyme that converts substrates into products using photosynthetically produced NAD(P)H.
- The research found that strong artificial electron sinks can outperform natural mechanisms, revealing that the pathway through ferredoxin-NAD(P)H-oxidoreductase is more effective for transferring photosynthetic electrons.
- Key findings highlight the importance of the NADPH/NADP+ ratio in regulating electron flow, suggesting that recognizing energy bottlenecks in engineered systems is vital for enhancing photosynthetic processes for sustainable production.
Towards the rate limit of heterologous biotechnological reactions in recombinant cyanobacteria.
Biotechnol Biofuels Bioprod
January 2023
Background: Cyanobacteria have emerged as highly efficient organisms for the production of chemicals and biofuels. Yet, the productivity of the cell has been low for commercial application. Cyanobacterial photobiotransformations utilize photosynthetic electrons to form reducing equivalents, such as NADPH-to-fuel biocatalytic reactions.
View Article and Find Full Text PDFThe microalga Nannochloropsis oceanica is considered a promising platform for the sustainable production of high-value lipids and biofuel feedstocks. However, current lipid yields of N. oceanica are too low for economic feasibility.
View Article and Find Full Text PDF