The Language of (Non)Replicable Social Science.

Using publicly available data from 299 preregistered replications from the social sciences, we found that the language used to describe a study can predict its replicability above and beyond a large set of controls related to the article characteristics, study design and results, author information, and replication effort. To understand why, we analyzed the textual differences between replicable and nonreplicable studies. Our findings suggest that the language in replicable studies is transparent and confident, written in a detailed and complex manner, and generally exhibits markers of truthful communication, possibly demonstrating the researchers' confidence in the study.

Treatment of Neovascular Age-Related Macular Degeneration: An Economic Cost-Risk Analysis of Anti-Vascular Endothelial Growth Factor Agents.

Purpose: To find the best cost-effective neovascular age-related macular degeneration (nAMD) treatment to improve vision while avoiding complications. The model is based on a cost-risk tradeoff analysis from policymakers' perspective.

Design: A powerful and flexible simulation modeled outcomes of 2 years of treatment with the 4 commonly used anti-vascular endothelial growth factor drugs (bevacizumab, ranibizumab, aflibercept, and brolucizumab) across 3 injection protocols, building on prior findings that these drugs are noninferior.