Publications by authors named "Michal Grzymajlo"
Article Synopsis
- Developed micro-sized hierarchical structures on PLLA surfaces to enhance cell adhesion and growth, using laser modification techniques.
- The structures feature round protrusions with specific dimensions, designed to increase surface roughness and promote non-cytotoxic interactions with cells.
- Experimental results showed that the laser-modified surfaces encouraged better adhesion of human fibroblasts and osteoblasts, while pathogenic bacteria adhered more uniformly, indicating potential for smart implants in regenerative medicine.
Article Synopsis
- This research focuses on synthesizing and characterizing a poly(glycerol sebacate) pre-polymer (pPGS) and incorporating nano-hydroxyapatite (HAp) to create a composite for biomedical applications.
- The microporous composites are developed through a series of processes including thermal cross-linking and salt leaching, and their structural properties are analyzed using various imaging and evaluation techniques.
- The results demonstrate that the PGS/HAp scaffolds exhibit excellent cytocompatibility and promote osteoblast differentiation while also showing potential for bone tissue reconstruction without adverse effects in vivo.
In this research we subjected samples of poly(L-lactide) (PLLA) extruded film to ultraviolet (193 nm ArF excimer laser) radiation below the ablation threshold. The modified film was immersed in Simulated Body Fluid (SBF) at 37 °C for 1 day or 7 days to obtain a layer of apatite ceramic (CaP) coating on the modified PLLA surface. The samples were characterized by means of optical profilometry, which indicated an increase in average roughness (Ra) from 25 nm for the unmodified PLLA to over 580 nm for irradiated PLLA incubated in SBF for 1 day.
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- Researchers developed foam scaffolds using poly(l-lactide) (PLLA) and apatite whiskers (HAP) through a thermally induced phase separation method supported by salt leaching to create various pore sizes.
- They investigated the internal structure and physical properties of the scaffolds through techniques like SEM and μCT, with particular success noted in the scaffolds made with larger salt sizes (500-600 μm) and l-lysine modification.
- The study found that these larger pore scaffolds enhanced osteoblast cell adhesion and proliferation, significantly improving calcium deposit formation compared to smaller pore scaffolds.