-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of Ga- and AlF-Labeled Radiopharmaceuticals.

Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important.

Calcium Carbonate Core-Shell Particles for Incorporation of Ac and Their Application in Local α-Radionuclide Therapy.

Actinium-225 (Ac) radiolabeled submicrometric core-shell particles (SPs) made of calcium carbonate (CaCO) coated with biocompatible polymers [tannic acid-human serum albumin (TA/HSA)] have been developed to improve the efficiency of local α-radionuclide therapy in melanoma models (B16-F10 tumor-bearing mice). The developed Ac-SPs possess radiochemical stability and demonstrate effective retention of Ac and its daughter isotopes. The SPs have been additionally labeled with zirconium-89 (Zr) to perform the biodistribution studies using positron emission tomography-computerized tomography (PET/CT) imaging for 14 days after intratumoral injection.