Characteristics of firearm injury by injury intent: The need for tailored interventions.

Introduction: While the United States has high quality data on firearm-related deaths, less information is available on those who arrive at trauma centers alive, especially those discharged from the emergency department. This study sought to describe characteristics of patients arriving to trauma centers alive following a firearm injury, postulating that significant differences in firearm injury intent might provide insights into injury prevention strategies.

Methods: This was a multicenter prospective cohort study of patients treated for firearm-related injuries at 128 US trauma centers from March 2021 to February 2022.

Emerging indoor photovoltaics for self-powered and self-aware IoT towards sustainable energy management.

As the number of Internet of Things devices is rapidly increasing, there is an urgent need for sustainable and efficient energy sources and management practices in ambient environments. In response, we developed a high-efficiency ambient photovoltaic based on sustainable non-toxic materials and present a full implementation of a long short-term memory (LSTM) based energy management using on-device prediction on IoT sensors solely powered by ambient light harvesters. The power is supplied by dye-sensitised photovoltaic cells based on a copper(ii/i) electrolyte with an unprecedented power conversion efficiency at 38% and 1.

Rapid and Facile Fabrication of Polyiodide Solid-State Dye-Sensitized Solar Cells Using Ambient Air Drying.

Dye-sensitized solar cells are promising candidates for low-cost indoor power generation applications. However, they currently suffer from complex fabrication and stability issues arising from the liquid electrolyte. Consequently, the so-called zombie cell was developed, in which the liquid electrolyte is dried out to yield a solid through a pinhole after cell assembly.

Assessment of TiO Blocking Layers for Cu-Electrolyte Dye-Sensitized Solar Cells by Electrochemical Impedance Spectroscopy.

The TiO blocking layer in dye-sensitized solar cells is the most difficult component to evaluate at thicknesses below 50 nm, but it is crucial for the power conversion efficiency. Here, the electrode capacitance of TiO blocking layers is tested in aqueous [Fe(CN)] and correlated to the performance of photoanodes in devices based on a [Cu(tmby)] electrolyte. The effects of the blocking layer on electronic recombination in the devices are illustrated with transient photovoltage methods and electrochemical impedance analysis.

National guideline for the field triage of injured patients: Recommendations of the National Expert Panel on Field Triage, 2021.

This work details the process of developing the updated field triage guideline, the supporting evidence, and the final version of the 2021 National Guideline for the Field Triage of Injured Patients.

The national trauma triage protocol: how EMS perspective can inform the guideline revision.

Objectives: The Field Triage Guidelines (FTG) support emergency medical service (EMS) decisions regarding the most appropriate transport destination for injured patients. While the components of the algorithm are largely evidenced-based, the stepwise approach was developed with limited input from EMS providers. FTG are only useful if they can easily be applied by the field practitioner.

Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections.

Both acute and chronic cutaneous wounds are often difficult to treat due to the high-risk for bacterial contamination. Once hospitalized, open wounds are at a high-risk for developing hospital-associated infections caused by multi drug-resistant bacteria such as and . Treating these infections is challenging, not only because of antibiotic resistance, but also due to the production of biofilms.

Survey of American College of Surgeons Members on Firearm Injury Prevention.

Background: Firearm-related injuries and deaths continue to be a substantial public health burden in the US. The purpose of this study was to describe the results of a survey of US members of the American College of Surgeons (ACS) on their practices, attitudes, and beliefs about firearms and firearm policies. The survey was designed to gain a representative understanding of the views of all US ACS members to help inform ACS positions related to firearm injury prevention.

Challenges and prospects of ambient hybrid solar cell applications.

The impending implementation of billions of Internet of Things and wireless sensor network devices has the potential to be the next digital revolution, if energy consumption and sustainability constraints can be overcome. Ambient photovoltaics provide vast universal energy that can be used to realise near-perpetual intelligent IoT devices which can directly transform diffused light energy into computational inferences based on artificial neural networks and machine learning. At the same time, a new architecture and energy model needs to be developed for IoT devices to optimize their ability to sense, interact, and anticipate.

Discovery of a Lead Compound for Specific Inhibition of Type I Collagen Production in Fibrosis.

Fibrosis is a major medical problem caused by excessive synthesis of the extracellular matrix, composed predominantly of type I collagen, in various tissues. There are no approved antifibrotic drugs, and the major obstacle in finding clinically relevant compounds is the lack of specificity of current experimental drugs for type I collagen. Here we describe the discovery of a lead compound that specifically inhibited secretion of type I collagen by fibroblasts in culture at IC = 4.

Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase.

Lemur tyrosine kinase 3 (LMTK3) is oncogenic in various cancers. In breast cancer, LMTK3 phosphorylates and modulates the activity of estrogen receptor-α (ERα) and is essential for the growth of ER-positive cells. LMTK3 is highly expressed in ER-negative breast cancer cells, where it promotes invasion via integrin β1.

Dye-sensitized solar cells under ambient light powering machine learning: towards autonomous smart sensors for the internet of things.

The field of photovoltaics gives the opportunity to make our buildings ''smart'' and our portable devices "independent", provided effective energy sources can be developed for use in ambient indoor conditions. To address this important issue, ambient light photovoltaic cells were developed to power autonomous Internet of Things (IoT) devices, capable of machine learning, allowing the on-device implementation of artificial intelligence. Through a novel co-sensitization strategy, we tailored dye-sensitized photovoltaic cells based on a copper(ii/i) electrolyte for the generation of power under ambient lighting with an unprecedented conversion efficiency (34%, 103 μW cm at 1000 lux; 32.

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries.

The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library TPI-1955 arranged on four sets of sublibraries (26 + 26 + 26 + 40), totaling 120 samples for testing provided information about the most important groups of each variable position in the TPI-1955 library containing 738,192 unique compounds. The parallel synthesis of the individual compounds derived from the deconvolution of the positional scanning library led to the identification of active selective antiplasmodial pyrrolidine bis-cyclic guanidines.

Nectar sampling for prairie and oak savanna butterfly restoration.

Premise Of The Study: Understanding floral resources is vital for restoring pollinators in habitats affected by anthropogenic development and climate change. As the primary adult food, nectar can limit butterfly longevity and reproduction. For pollinator restoration, it would therefore be useful to examine nectar resources.

When it pays to cheat: Examining how generalized food deception increases male and female fitness in a terrestrial orchid.

Background: Experimental manipulations of floral nectar in food deceptive species can reveal insights into the evolutionary consequences of the deceptive strategy. When coupled to pollen tracking, the effects of the deceptive pollination syndrome on both male and female reproductive success may be quantified. Attraction of pollinators in deceit-pollinated species often relies on producing a conspicuous floral display which may increase visibility to pollinators, but in-turn may increase within plant selfing.

Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines.

Parallel solid phase synthesis offers a unique opportunity for the synthesis and screening of large numbers of compounds and significantly enhances the prospect of finding new leads. We report the synthesis and antitubercular activity of chiral 1,2,4-trisubstituted piperazines derived from resin bound acylated dipeptides against Mycobacterium tuberculosis strain H37Rv.

A reassessment of the impact of trauma systems consultation on regional trauma system development.

Background: Previous studies have shown that trauma systems decrease morbidity and mortality after injury, but progress in system development has been slow and inconsistent. This study evaluated the progress in 20 state or regional systems following a consultative visit conducted by the Trauma Systems Evaluation and Planning Committee (TSEPC) of the Committee on Trauma, expanding on a previous study published in 2008, which demonstrated significant progress in six systems following consultation.

Methods: Twenty trauma systems that underwent TSEPC consultation between 2004 and 2010 were studied.

A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects.

Background/objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects.

Subjects/methods: Eighteen individuals meeting BP requirements (⩾130 mm Hg systolic or ⩾85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.

Is it time to call it quits on low-dose quetiapine?

The mandate of the Centers for Medicare & Medicaid Services to decrease the use of antipsychotics in long-term care facilities requires creative solutions. Low-dose quetiapine is used for a multitude of behavioral disorders and sleep problems in the nursing facility population. Yet, at doses of 25 mg per day or less, it doesn't have strong affinity (if any) for the dopamine-2 (D2) receptor, but it does maintain affinity for the histamine-1 and alpha-1 receptors.

Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections.

Tedizolid phosphate is the first once-daily oxazolidinone approved by the United States Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections (ABSSSI). It is more potent in vitro than linezolid against methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive pathogens causing ABSSSI, even retaining activity against some linezolid-resistant strains. Tedizolid is approximately 90% protein bound, leading to lower free-drug concentrations than linezolid.