Publications by authors named "Michaela Tutone"
Urinary tract infections (UTIs) are prevalent worldwide, particularly among women. Their incidence increases with age, and treatment is increasingly challenging owing to antibiotic resistance and the lack of new agents. We investigated the susceptibility of current urinary isolates to fosfomycin and other antibiotics across Europe.
View Article and Find Full Text PDFParkinson's disease patients suffer from both motor and nonmotor impairments. There is currently no cure for Parkinson's disease, and the most commonly used treatment, levodopa, only functions as a temporary relief of motor symptoms. Inhibition of the expression of the L-tryptophan-catabolizing enzyme tryptophan 2,3-dioxygenase (TDO) has been shown to inhibit aging-related α-synuclein toxicity in Caenorhabditis elegans.
View Article and Find Full Text PDFHow Do Drug Regulatory Bodies Deal With Potential Innovative Therapies?
Ther Innov Regul Sci
January 2020
Article Synopsis
- Regulatory authorities (RAs) have been working hard to figure out how to identify and manage new and innovative drugs over the last 10 years.
- The article looks at how RAs in different countries (like Europe, USA, Canada, Australia, and Japan) determine which drugs are innovative and compares their methods.
- All RAs focus on two main things to help get new drugs to patients faster: speeding up approval times and managing the limited information available about these drugs.
Objectives: The aim of this paper is to investigate the determinants of the difference between the price proposal submitted by the industry and the final negotiated price. We used Italy as a case-study.
Methods: Data were gathered through the information system used by Italian Medicines Agency.