Quantitative proteomic analysis of cerebrospinal fluid of women newly diagnosed with multiple sclerosis.

Purpose: The lack of reliable diagnostic and/or prognostic biomarkers for multiple sclerosis (MS) is the major obstacle to timely and accurate patient diagnosis in MS patients. To identify new proteins associated with MS we performed a detailed proteomic analysis of cerebrospinal fluid (CSF) of patients newly diagnosed with relapsing-remitting MS (RRMS) and healthy controls.

Material: Reflecting significantly higher prevalence of MS in women we included only women patients and controls in the study.