Publications by authors named "Michaela Lellig"
Article Synopsis
- Angiotensin II (Ang II) is crucial for blood pressure regulation, and a modified version called pyruvamide-Ang II (Ang P), created with a cheaper vitamin B derivative (pyridoxal-5'-phosphate), may provide a cost-effective treatment for hypertension.
- Studies showed that Ang P leads to lower calcium entry in vascular smooth muscle cells and has a weaker binding affinity to the angiotensin II type 1 receptor, resulting in less vasoconstriction compared to traditional Ang II.
- In tests on rats, using PLP significantly reduced blood pressure in spontaneously hypertensive rats and prevented blood pressure spikes in normal rats when treated with both Ang II and PLP, suggesting
Article Synopsis
- Emerging evidence indicates that cellular senescence plays a crucial role in chronic kidney disease (CKD), with proximal tubule epithelial cells (PTECs) and fibroblasts being key contributors to this condition.
- Researchers developed a new human kidney cell model by isolating PTECs and fibroblasts and introducing a specific viral vector, allowing them to better mimic real kidney cells and study their behaviors.
- The study found that senescent PTECs can trigger fibrosis in fibroblasts, and the presence of p21-positive cells in kidney sections correlated with more severe fibrosis and reduced kidney function, thereby underscoring the importance of cellular senescence in CKD.
Article Synopsis
- Tubular injury is a key problem in acute kidney injury (AKI) that affects both patients and healthcare systems.
- Researchers created special mice to study how certain kidney cells change during injury and can return to normal after healing.
- The study found that these injured cells can revert back to their healthy state once the injury is treated, showing that the kidney has a way to adapt and recover.
Background: Coexistent CKD and cardiovascular diseases are highly prevalent in Western populations and account for substantial mortality. We recently found that apolipoprotein C-3 (ApoC3), a major constituent of triglyceride-rich lipoproteins, induces sterile systemic inflammation by activating the NOD-like receptor protein-3 (NLRP3) inflammasome in human monocytes via an alternative pathway.
Methods: To identify posttranslational modifications of ApoC3 in patients with CKD, we used mass spectrometry to analyze ApoC3 from such patients and from healthy individuals.
Purpose: Biopsies are a diagnostic tool for the diagnosis of histopathological, molecular biological, proteomic, and imaging data, to narrow down disease patterns or identify diseases. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) provides an emerging state-of-the-art technique for molecular imaging of biological tissue. The aim of this study is the registration of MALDI MSI data sets and data acquired from different histological stainings to create a 3D model of biopsies and whole organs.
View Article and Find Full Text PDFMatrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MALDI MSI) has become a powerful tool with a high potential relevance for the analysis of biomolecules in tissue samples in the context of diseases like cancer and cardiovascular or cardiorenal diseases. In recent years, significant progress has been made in the technology of MALDI MSI. However, a more systematic optimization of sample preparation would likely achieve an increase in the molecular information derived from MALDI MSI.
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