Publications by authors named "Michaela Kacerovsky"
Objective: Muscle insulin resistance has been implicated in the development of steatosis and dyslipidemia by changing the partitioning of postprandial substrate fluxes. Also, insulin resistance may be due to reduced mitochondrial function. We examined the association between mitochondrial activity, insulin sensitivity, and steatosis in a larger human population.
View Article and Find Full Text PDFObjective: Myocellular ATP synthesis (fATP) associates with insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Short-term endurance training can modify their fATP and insulin sensitivity. This study examines the effects of moderate long-term exercise using endurance or resistance training in this cohort.
View Article and Find Full Text PDFObjective: Intravenous insulin infusion partly improves liver glucose fluxes in type 1 diabetes (T1D). This study tests the hypothesis that continuous subcutaneous insulin infusion (CSII) normalizes hepatic glycogen metabolism.
Research Design And Methods: T1D with poor glycemic control (T1Dp; HbA(1c): 8.
Article Synopsis
- The study explored how short-term exercise training affects hereditary insulin resistance by increasing ATP synthesis in individuals.
- Results showed that first-degree relatives of type 2 diabetes patients had lower insulin sensitivity and ATP synthesis compared to controls, but those who improved ATP production after exercise also improved their insulin sensitivity.
- A specific gene polymorphism in NDUFB6 was linked to variations in ATP synthesis and insulin sensitivity responses to exercise, suggesting genetic factors play a role in how individuals adapt to exercise training.
Objective: Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion.
Research Design And Methods: We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyocellular lipids [IMCLs]) using (31)P/(1)H magnetic resonance spectroscopy and insulin sensitivity and endogenous glucose production (EGP) using hyperinsulinemic-euglycemic clamps combined with isotopic tracer dilution in one female patient suffering from MELAS (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome and in six control subjects.