Histopathology of Neovascularisation Observed During Saphenofemoral Re-Do High Ligation.

Objective: The primary aim of this study was to assess the histopathological criteria of neovascularisation following saphenofemoral high ligation with regard to the delineation of the pathophysiology of the process. The secondary aims were to describe the perivenous morphological changes and to present cost effective agents to histopathologically diagnose neovascularisation.

Methods: In a prospective study design, vein samples of consecutive patients with recurrent varicose veins in the groin undergoing surgery were collected.

Pain-related functional interference in patients with chronic neuropathic postsurgical pain: an analysis of registry data.

Although chronic postsurgical pain (CPSP) is a major health care problem, pain-related functional interference has rarely been investigated. Using the PAIN OUT registry, we evaluated patients' pain-related outcomes on the first postoperative day, and their pain-related interference with daily living (Brief Pain Inventory) and neuropathic symptoms (DN4: douleur neuropathique en 4 questions) at 6 months after surgery. Endpoints were pain interference total scores (PITS) and their association with pain and DN4 scores.