Effect of Osteoblast-Specific Deletion of the Proton Receptor OGR1.

Metabolic acidosis (MET) stimulates bone resorption through inhibition of osteoblast (OB) bone formation and stimulation of osteoclast (OC) bone resorption. We found that OGR1, a G protein-coupled proton (H)-sensing receptor, was critical for initial H signaling in the OB. In mice with a global deletion of OGR1, we demonstrated that loss of OGR1 impairs H-induced bone resorption, leading to increased bone density through effects on both the OB and OC.

Questioning Marriage and Family Norms.

In , a woman is stressed by unsolicited opinions and frequent insinuations that marriage inevitably leads to babies. She laments, "Even the pope's got an opinion!," in response to his suggestion that selfishness motivates couples who choose not to have children.

How Well Do We See White Supremacy as a Source of Harm in the Culture of Medicine?

is a comic that investigates cultures' limitations in identifying and investigating their own blind spots. In health care, for example, medicine is a culture not always well equipped to see its capacity to harm patients or to save itself from harm incursion mechanisms endemic to White supremacy, which medicine has long promoted, intentionally or not, throughout its history.

Appetites Are Not Ethically Neutral.

The comic illustrates an irony at play: a patient's gift of a box of donuts is offered in thanks just as a physician recommends "more vegetables and less refined sugars."

At War With Bodies' Limits.

In American culture, blood, sweat, and tears mantras of sports remind athletes that they are expected to perform past their breaking point. This comic considers this expectation narratively and visually.

Public Health Risk and Civic Peership.

During the COVID-19 pandemic, some US federal courts required jurors' vaccination against COVID-19, which, according to some, made a juror less representative of a peer. This comic investigates this set of concerns narratively and visually.

Contraception Options.

considers the general social and cultural expectation and norm that women's bodies should be the sites of contraception. The comic represents frustration with inequitable distribution of contraceptive burden.

Kidney stone formation and the gut microbiome are altered by antibiotics in genetic hypercalciuric stone-forming rats.

Antibiotics can alter the gut microbiome (GMB), which may be associated with stone disease. We sought to determine the effect that antibiotics have on the GMB, urine ion excretion and stone formation in genetic hypercalciuric stone-forming (GHS) rats. 116th generation GHS rats were fed a fixed amount of a normal calcium (1.

Deletion of the proton receptor OGR1 in mouse osteoclasts impairs metabolic acidosis-induced bone resorption.

Metabolic acidosis induces osteoclastic bone resorption and inhibits osteoblastic bone formation. Previously we found that mice with a global deletion of the proton receptor OGR1 had increased bone density although both osteoblast and osteoclast activity were increased. To test whether direct effects on osteoclast OGR1 are critical for metabolic acidosis stimulated bone resorption, we generated knockout mice with an osteoclast-specific deletion of OGR1 (knockout mice).