Rotavirus vaccination in a Medicaid infant population from four US states: compliance, vaccination completion rate, and predictors of compliance.

A retrospective observational cohort study was conducted using Medicaid administrative claims data from four states in the United States (US) to analyze overall and state-specific compliance and completion rates for rotavirus (RV) vaccines. Compliance was based on an infant receiving the recommended number of doses each within the appropriate time frame, and completion was based on an infant receiving the recommended number of doses over a recommended time period. Compliance and completion were defined separately for RV vaccines by package insert (PI) and Advisory Committee on Immunization Practices (ACIP) guidelines.

Impact of increasing adherence to disease-modifying therapies on healthcare resource utilization and direct medical and indirect work loss costs for patients with multiple sclerosis.

Objectives: To estimate the effect of adherence to disease-modifying therapies (DMTs) among patients with multiple sclerosis (MS) on healthcare resource utilization (HRU) and costs, and model the impact of a 10 percentage point increase in adherence on these outcomes.

Methods: Employed patients, 18-64 years old, with ≥2 MS diagnoses and ≥1 DMT claim during January 1, 2002 to September 30, 2012 were identified from a large commercially-insured US claims database. Adherence was measured as proportion of days covered (PDC) during follow-up.