An induced extrinsic tooth stain prevention model to investigate whitening potential of sugar-free chewing gums.

Purpose: To establish an accelerated clinical test method to evaluate the effectiveness of sugar-free gums in prevention of the formation of extrinsic stains when chewed over a 2-week period in conjunction with daily tooth brushing. A secondary objective was to compare three methods for measuring extrinsic stain.

Methods: 25 healthy adult volunteers were enrolled in a single center, examiner blind, randomized 4-way crossover clinical study.