Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change.

Introduction: Stress-induced hyperglycaemia is prevalent in critical care. Control of blood glucose levels to within a 4.4 to 6.

Model-based insulin and nutrition administration for tight glycaemic control in critical care.

Objective: Present a new model-based tight glycaemic control approach using variable insulin and nutrition administration.

Background: Hyperglycaemia is prevalent in critical care. Current published protocols use insulin alone to reduce blood glucose levels, require significant added clinical effort, and provide highly variable results.

Clinical validation of a model-based glycaemic control design approach and comparison to other clinical protocols.

Hyperglycaemia is prevalent in critical care and tight control can reduce mortality from 9-43% depending on the level of control and the cohort. This research presents a table-based method that varies both insulin dose and nutritional input to achieve tight control. The system mimics a previously validated model-based system, but can be used for long term, large patient number clinical evaluation.

Rethinking glycaemic control in critical illness--from concept to clinical practice change.

Objective: To examine the practical difficulties in managing hyperglycaemia in critical illness and to present recently developed model-based glycaemic management protocols to provide tight control.

Background: Hyperglycaemia is prevalent in critical care. Current published protocols require significant added clinical effort and have highly variable results.