Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo.

Purpose: This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo.

Methods: Corneal haze in rabbits was produced with -9.00 diopter PRK.

Vorinostat: a potent agent to prevent and treat laser-induced corneal haze.

Purpose: This study investigated the efficacy and safety of vorinostat, a deacetylase (HDAC) inhibitor, in the treatment of laser-induced corneal haze following photorefractive keratectomy (PRK) in rabbits in vivo and transforming growth factor beta 1 (TGFβ1) -induced corneal fibrosis in vitro.

Methods: Corneal haze in rabbits was produced with -9.00 diopters (D) PRK.

Implementing computerized physician order management at a community hospital.

Background: In 2000, four community hospitals in the Cleveland Clinic Health System embarked on an electronic medical record (EMR) project to create an integrated information management environment and improve clinical decision making.

Methods: Executives and individuals from many departments and disciplines were organized into a project structure to launch the project, make decisions, and accomplish change management, which addressed communication, work-flow redesign, training, and support during transition to the new technology-enabled process.

Project: In 1999, a small group of regional information technology (IT) leaders for four community hospitals operated by the Cleveland Clinic Health System in the East Region developed a project for the implementation of computerized physician order management (CPOM).

Cleveland Clinic Health System: A comprehensive framework for a health system patient safety initiative.

The Cleveland Clinic Health System (CCHS) is committed to the enhancement of patient safety throughout the CCHS. This article describes the CCHS patient safety initiative, the development, objectives, strategies, goals, and activities.

Introducing the quality Institute of the Cleveland Clinic Health System.

Several quality measurement needs surfaced when the Cleveland Clinic Health System (CCHS) was formed, including a need for standardized measurement of clinical processes and outcomes, patient satisfaction, critical care, and patient safety. The Quality Institute (QI) facilitates system teams to address these issues, manages selection of measurement tools, collects and analyzes performance data, coordinates presentations, and presents team findings. The QI manages the CCHS performance improvement plan and coordinates activities designed to accomplish priority goals, in collaboration with multiple CCHS teams and the regional and hospital staffs.