Publications by authors named "Michael W Norsworthy"
Article Synopsis
- Lake Malawi cichlids show significant diversity in their physical traits and behaviors due to a small number of genetic changes, primarily in non-coding regions of their DNA.
- A large majority (96%) of these genetic differences are found in non-coding sequences that are still evolutionarily conserved and linked to important traits like facial structure, neural functions, and behaviors.
- The study highlights the potential of using genome sequencing to understand evolutionary changes, as research on genetic differences in cichlids predicts variations in important traits and behaviors in natural populations.
At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could reprogram them to a "youthful" growth-competent state and promote regeneration of other types.
View Article and Find Full Text PDFMitochondrial transport is crucial for neuronal and axonal physiology. However, whether and how it impacts neuronal injury responses, such as neuronal survival and axon regeneration, remain largely unknown. In an established mouse model with robust axon regeneration, we show that Armcx1, a mammalian-specific gene encoding a mitochondria-localized protein, is upregulated after axotomy in this high regeneration condition.
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