Inflammatory Myofibroblastic Tumor of the Esophagus and Stomach Successfully Treated With ALK Inhibitor in a Pediatric Patient: A Case Report and Concise Review of Literature.

An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of borderline malignant potential. Nearly half of all IMTs have rearrangement of anaplastic lymphoma kinase (ALK) locus on chromosome 2p23 which can be treated with targeted therapy. Herein, we describe an unusual presentation of IMT involving an anatomical region rarely implicated in this disease process.

The effect of configural processing on mentalization.

Eight studies ( = 2,561) reveal that how we perceptually process a person's face affects our capacity to understand their mind. Studies 1A and B indicate this relationship functions via two separate pathways: (a) indirectly by increasing our sensitivity to the cues of a mind in a face and (b) directly by changing the way we relate to the mind behind the face. Six additional studies adopt perspective taking paradigms to provide further support for a direct effect of configural processing on mentalization.

A Case of Malignant Brenner Tumor of the Ovary Incidentally Found in a Patient with Deep Vein Thrombosis.

We present the case of a 73-year-old woman who was incidentally found to have a malignant Brenner tumor (MBT) of the ovary during an evaluation for deep vein thrombosis (DVT). The patient presented with swelling in her left leg, non-healing ulcers, weakness, and numbness in her lower limbs. Imaging studies revealed a large multiloculated cystic mass with areas of calcification in the left adnexa extending to the upper abdomen toward the gallbladder fossa.

Population Density and Triage of Pediatric Firearm Injuries in a Rural Trauma System.

Background: Rural pediatric firearm injuries require regional pediatric and trauma expertise. We evaluated county-level population density associations with transport, hospital interventions, and patient outcomes at a Level I pediatric trauma center serving a rural, statewide catchment area.

Material And Methods: The trauma registry of the only in-state pediatric trauma center was reviewed for firearm injuries in patients < 18 between 1/2013 and 3/2020.

The surprising underperformance of East Asians in US law and business schools: The liability of low assertiveness and the ameliorative potential of online classrooms.

SignificanceTo date, researchers and practitioners have focused on the academic challenges of underrepresented ethnic groups in the United States. In comparison, Asians have received limited attention, as they are commonly assumed to excel across all educational stages. Six large studies challenge this assumption by revealing that East Asians (but not South Asians) underperform in US law schools and business schools.

Left-Sided Amyand Hernia.

An Amyand's hernia is defined by the presence of the vermiform appendix in the inguinal hernia sac. Most cases of Amyand's hernia are incidentally diagnosed intraoperatively while surgically reducing a right inguinal hernia. Right-sided Amyand's hernias are more common than left-sided Amyand's hernias for two reasons: the appendix is naturally located on the right side and right inguinal hernias are more common.

Experiential learning of cultural norms: The role of implicit and explicit aptitudes.

How should I greet her? Should I do what he requests? Newcomers to a culture learn its interpersonal norms at varying rates, largely through trial-and-error experience. Given that the culturally correct response often depends on conditions that are subtle and complex, we propose that newcomers' rate of acculturation depends on not only their explicit aptitude (e.g.

Closed Gastroschisis: A Rare Abdominal Wall Defect.

Gastroschisis is a rare congenital abdominal wall defect characterized by intestinal evisceration to the right of the umbilical stalk. In less than 6% of cases, the fascial defect closes around the herniated viscera in utero. The mechanism of fascial closure in these cases is unknown; however, the tourniquet effect on the mesenteric vasculature is thought to lead to intestinal atresia and midgut infarction.

How Does Collectivism Affect Social Interactions? A Test of Two Competing Accounts.

How does the cultural construct of collectivism impact social interactions? Two accounts of collectivism offer diverging predictions. The collectivism-as-values account proposes that people in collectivistic cultures prioritize their ingroup relationships; accordingly, this account predicts that collectivistic cultures will have more harmonious ingroup interactions than individualistic cultures. The socioecological account holds that individualistic cultures have high relational mobility, which requires people to invest in their ingroup relationships, whereas collectivistic cultures feature more fixed relationships that do not require positive engagement.

Why East Asians but not South Asians are underrepresented in leadership positions in the United States.

Well-educated and prosperous, Asians are called the "model minority" in the United States. However, they appear disproportionately underrepresented in leadership positions, a problem known as the "bamboo ceiling." It remains unclear why this problem exists and whether it applies to all Asians or only particular Asian subgroups.

Pediatric Appendicitis-Factors Associated With Surgical Approach, Complications, and Readmission.

Background: Laparoscopic appendectomy is a preferred approach in children with appendicitis. Patient characteristics associated with open appendectomy are poorly characterized, although such information can help optimize the care.

Material And Methods: To characterize the factors associated with open appendectomy, we performed a retrospective analysis using the 2014 Nationwide Readmissions Database, capturing 49.

Ingroup vigilance in collectivistic cultures.

Collectivistic cultures have been characterized as having harmonious, cooperative ingroup relationships. However, we find evidence that people in collectivistic cultures are more vigilant toward ingroup members, mindful of their possible unethical intentions. Study 1 found that Chinese participants were more vigilant than Americans in within-group competitions, anticipating more unethical behaviors from their peers.

Metacognition fosters cultural learning: Evidence from individual differences and situational prompts.

We investigated the role of metacognition in the process by which people learn new cultural norms from experiential feedback. In a lab paradigm, participants received many trials of simulated interpersonal situations in a new culture, each of which required them to make a choice, and then provided them with evaluative feedback about the accuracy of their choice with regard to local norms. Studies 1 to 3 found that participants higher on an individual difference dimension of metacognitive proclivity learned to adhere to the local norms faster.

Understanding the MBA Gender Gap: Women Respond to Gender Norms by Reducing Public Assertiveness but Not Private Effort.

Women's underperformance in MBA programs has been the subject of recent debate and policy interventions, despite a lack of rigorous evidence documenting when and why it occurs. The current studies document a performance gap, specifying its contours and contributing factors. Two behaviors by female students that may factor into the gap are public conformity and private internalization.

Adaptive Appraisals of Anxiety Moderate the Association between Cortisol Reactivity and Performance in Salary Negotiations.

Prior research suggests that stress can be harmful in high-stakes contexts such as negotiations. However, few studies actually measure stress physiologically during negotiations, nor do studies offer interventions to combat the potential negative effects of heightened physiological responses in negotiation contexts. In the current research, we offer evidence that the negative effects of cortisol increases on negotiation performance can be reduced through a reappraisal of anxiety manipulation.

Multicultural identity processes.

The study of multicultural identity has gained prominence in recent decades and will be even more urgent as the mobility of individuals and social groups becomes the 'new normal'. This paper reviews the state-of-the-art theoretical advancements and empirical discoveries of multicultural identity processes at the intrapersonal, interpersonal, and collective (e.g.

Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression.

Background: Endoplasmic reticulum (ER) stress and autophagy each play important roles in hepatocyte cell injury. We hypothesized that gene expression of C/EBP-homologous protein (CHOP) and the BH3 proteins Bcl2-interacting mediator of cell death (BIM) and BH3-interacting domain death agonist (BID) are involved in a complex interplay that regulates ER stress-induced autophagy and cell death.

Materials And Methods: Hepatocytes were cultured from lean Zucker rats.

Polycultural psychology.

We review limitations of the traditional paradigm for cultural research and propose an alternative framework, polyculturalism. Polyculturalism assumes that individuals' relationships to cultures are not categorical but rather are partial and plural; it also assumes that cultural traditions are not independent, sui generis lineages but rather are interacting systems. Individuals take influences from multiple cultures and thereby become conduits through which cultures can affect each other.

Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation.

Wound size impacts the threshold between scarless regeneration and reparative healing in the fetus with increased inflammation showed in fetal scar formation. We hypothesized that increased fetal wound size increases pro-inflammatory and fibrotic genes with resultant inflammation and fibroplasia and that transition to scar formation could be reversed by overexpression of interleukin-10 (IL-10). To test this hypothesis, 2-mm and 8-mm dermal wounds were created in mid-gestation fetal sheep.

Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult.

Background: In adults, myocardial infarction (MI) results in a brisk inflammatory response, myocardium loss, and scar formation. We have recently reported the first mammalian large-animal model of cardiac regeneration after MI in fetal sheep. We hypothesize that the ability of the fetus to regenerate functional myocardium after MI is owing to differential gene expression regulating the response to MI in the fetus compared with the adult.

Cardiac Progenitor Cells in Myocardial Infarction Wound Healing: A Critical Review.

Significance: Coronary artery disease is a major cause of morbidity and mortality as the loss of functional myocardium drives progressive ventricular remodeling and subsequent heart failure. Medical management has significantly improved outcomes for acute myocardial infarction (MI); however, improved strategies are needed to regenerate functional myocardium and prevent the progression to heart failure. Cytotherapy using cardiac progenitor cells (PCs) to regenerate functional myocardium holds tremendous potential; however, a better understanding of PC biology is needed.

Necrotizing fasciitis of the perineum associated with a bartholin abscess.

Background: Perineal gangrene was first described in healthy, young males more than two and one-half centuries ago. This disease, referred to commonly as Fournier gangrene, was marked by rapid progression, high mortality, and unknown etiology. In the last century the pathologic processes were described and accounts of perineal gangrene were reported in females.