Publications by authors named "Michael W Mikula"

Article Synopsis
  • The sinonasal tract includes two main tumor types with neuroectodermal differentiation: Olfactory neuroblastoma (ONB) and the newly-recognized Olfactory carcinoma (OC).
  • ONB is characterized as a keratin-negative tumor with a lobulated structure, while OC is keratin-positive and often has well-formed glands present.
  • The review aims to clarify the clinical and diagnostic features of ONB and OC, and how they can be differentiated from other similar tumors in the sinonasal area.
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Testing for enteric bacterial pathogens in patients hospitalized for more than 3 days is almost always inappropriate. Our study validates the utility of the 3-day rule and the use of clinical decision support tools to decrease unnecessary testing of enteropathogenic bacteria other than . Overriding the restriction was very low yield.

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Background: Inflammation and structural remodeling may contribute to fibrogenesis in Crohn's disease (CD). We quantified the immunoexpression of calretinin, CD34, and calprotectin as a surrogate for mucosal innervation, telocytes (interstitial cells playing a role in networking), and inflammation, respectively, and correlated them with bowel alterations in stricturing CD.

Methods: Primary resection specimens for ileal CD (n = 44, 31 stricturing CD, 13 inflammatory CD) were identified.

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Although low-grade non-intestinal-type sinonasal adenocarcinoma (SNAC) is formally a diagnosis of exclusion defined by the absence of salivary or intestinal differentiation, most tumors in this category comprise a distinctive histologic group that are increasingly thought to derive from seromucinous glands. However, the molecular underpinnings of SNAC remain poorly understood, and it is unclear if diverse genetic alterations recently reported in isolated cases should delineate separate subgroups. This study aims to perform comprehensive evaluation of gene fusions and mutations and their histologic correlates in low-grade SNAC to clarify its pathogenesis and classification.

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Article Synopsis
  • A global survey revealed a significant decrease in the number of cytological specimens processed during the post-lockdown period of 2020, compared to 2019, with a drop of 26.5%.
  • Despite fewer specimens, the malignancy rates increased notably, indicating potential unmet needs in cancer diagnosis during the pandemic.
  • The data suggests a gradual return to normalcy in cytopathology practices, as seen in the increased workload late in the post-lockdown phase.
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Crohn's disease of the pouch (CDP) is seen in a subset of ulcerative colitis (UC) patients following ileal pouch-anal anastomosis (IPAA). Histologic or clinical predictors of CDP are unknown. UC patients with subsequent CDP diagnosis were identified.

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