Antibiotic dosing during sustained low-efficiency dialysis: special considerations in adult critically ill patients.

Objective: To address issues of antibiotic dosing during sustained low-efficiency dialysis by using available pharmacokinetic data, intermittent and continuous renal replacement therapy dialysis guidelines, and our experience with sustained low-efficiency dialysis.

Data Resources: Published clinical trials, case reports, and reviews of antibiotic dosing in humans during sustained low-efficiency dialysis.

Data Extraction: A search of electronic databases (MEDLINE, PubMed, and Ovid) was conducted by using key words of extended daily dialysis, sustained low-efficiency dialysis, antibiotics, antimicrobial agents, and pharmacokinetics.