Selective hippocampal subfield volume reductions in classic trigeminal neuralgia.

Trigeminal Neuralgia (TN) is a chronic neuropathic pain syndrome characterized by paroxysmal unilateral shock-like pains in the trigeminal territory most frequently attributed to neurovascular compression of the trigeminal nerve at its root entry zone. Recent advances in the study of TN suggest a possible central nervous system (CNS) role in modulation and maintenance of pain. TN and other chronic pain patients commonly experience alterations in cognition and affect, as well as abnormalities in CNS volume and microstructure in regions associated with pain perception, emotional modulation, and memory consolidation.

Systematic review and meta-analysis of T1 glottic cancer outcomes comparing CO transoral laser microsurgery and radiotherapy.

Background: The objective of this study is to compare the oncologic outcomes of CO transoral laser microsurgery (TLM) and radiotherapy (RT) for treatment of T1 glottic carcinoma.

Methods: A literature search was conducted in the following databases: Medline/PubMed, Web of Science, EMBASE, and the Cochrane Library. Search results were screened, and publications comparing oncologic outcomes of T1N0M0 glottic carcinoma treated with TLM or RT were included.

Cross sectional analysis of student-led surgical societies in fostering medical student interest in Canada.

Background: The objective of this study was to examine how surgery interest groups (SIGs) across Canada function and influence medical students' interest in surgical careers.

Methods: Two unique surveys were distributed using a cross sectional design. The first was sent to SIG executives and the second to SIG members enrolled at a Canadian medical school in the 2016/17 academic year.

Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2.

Mutations in the presenilin genes (PS1 and PS2) are a major cause of familial-Alzheimer's disease (FAD). Presenilins regulate neurogenesis in the developing brain, with loss of PS1 inducing aberrant premature differentiation of neural progenitor cells, and additional loss of PS2 exacerbating this effect. It is unclear, however, whether presenilins are involved in adult neurogenesis, a process that may be impaired in Alzheimer's disease within the hippocampus.