Impact of time interval from cesarean delivery to frozen embryo transfer on reproductive and neonatal outcomes.

Objective: To evaluate differences in reproductive and neonatal outcomes on the basis of the time interval from cesarean delivery to subsequent frozen embryo transfer (FET).

Design: Retrospective cohort.

Setting: Multicenter fertility practice.

Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors.

Cyclophosphamide is associated with chemotherapy-related ovarian failure (CROF) in breast cancer survivors, however little is known about predicting individual risks. We sought to identify genetic alleles as biomarkers for risk of CROF after cyclophosphamide treatment. One hundred fifteen premenopausal women with newly diagnosed breast cancer were genotyped for single nucleotide polymorphisms (SNPs) in genes involved in cyclophosphamide activation ( and and detoxification ( and ).

Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome.

Context: In women with polycystic ovary syndrome (PCOS), 17-hydroxyprogesterone (17-OHP) responses to gonadotropin stimulation vary from increased to indistinguishable compared with normal controls.

Objective: To determine whether 17-OHP responses to recombinant-human chorionic gonadotropin (r-hCG) are individually correlated to the size of antral follicles among women with PCOS.

Design Setting And Participants: A prospective study conducted in 19 women with PCOS and 20 normal controls at an academic medical center.

In vitro fertilization, interpregnancy interval, and risk of adverse perinatal outcomes.

Objective: To compare associations between interpregnancy intervals (IPIs) and adverse perinatal outcomes in deliveries following IVF with deliveries following spontaneous conception or other (non-IVF) fertility treatments.

Design: Cohort using linked birth certificate and assisted reproductive technology surveillance data from Massachusetts and Michigan.

Setting: Not applicable.

The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome.

Background: The influence of estradiol (E) on granulosa cell (GC) function has not been tested clinically in women with polycystic ovary syndrome (PCOS). The objective of this study is to determine if E influences GC responses to FSH in women with PCOS.

Methods: This is a two phase, single cohort study conducted over a 2-year period at a single academic center.

Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors.

Objective: To determine if interindividual genetic variation in single-nucleotide polymorphisms (SNPs) related to age at natural menopause is associated with risk of ovarian failure in breast cancer survivors.

Methods: A prospective cohort of 169 premenopausal breast cancer survivors recruited at diagnosis with stages 0 to III disease were followed longitudinally for menstrual pattern via self-reported daily menstrual diaries. Participants were genotyped for 13 SNPs previously found to be associated with age at natural menopause: EXO1, TLK1, HELQ, UIMC1, PRIM1, POLG, TMEM224, BRSK1, and MCM8.

Comparability of antimüllerian hormone levels among commercially available immunoassays.

Objective: To compare antimüllerian hormone (AMH) levels among three commercially available AMH immunoassays: AMH Gen II (Beckman Coulter), Ultrasensitive AMH (Ansh Labs), and picoAMH (Ansh Labs).

Design: Cross-sectional.

Setting: Academic reproductive endocrinology program.