Publications by authors named "Michael Tun Yin Lam"
Article Synopsis
- The study investigates the transcription factor programs involved in the immune response to COVID-19, focusing on the significance of capturing active transcription initiation using csRNA-seq instead of conventional RNA-seq to better understand transcription factor activity.
- Researchers analyzed critically ill COVID-19 patients and identified specific transcription factor motifs linked to lung injury and disease severity, highlighting distinct subsets of regulatory elements based on cell type and pathways.
- The findings indicate that certain regulatory networks, particularly those involving STAT/BCL6 and E2F/MYB, are activated in patients with worse outcomes, suggesting a connection between these networks and COVID-19 susceptibility genetic variants, ultimately enhancing our understanding of disease mechanisms and patient stratification
Article Synopsis
- The study investigates how transcription factors (TFs) and gene regulatory programs influence immune responses in critically ill COVID-19 patients, particularly in relation to lung injury severity and disease outcomes.
- By analyzing the "active cistrome" of peripheral leukocytes, researchers identified key TF motifs that correlate with COVID-19 severity and recovery.
- The findings indicate that certain TF regulatory networks, particularly those involving STAT and E2F/MYB, are prominent in myeloid cells of patients with poor outcomes, providing insights into potential mechanisms influencing disease progression.
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a key role in tumorigenesis and facilitates the establishment of cancer hallmarks. Conversely, oncogenic processes directly weaken circadian rhythms.
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