Prohormones in the Early Diagnosis of Cardiac Syncope.

Background: The early detection of cardiac syncope is challenging. We aimed to evaluate the diagnostic value of 4 novel prohormones, quantifying different neurohumoral pathways, possibly involved in the pathophysiological features of cardiac syncope: midregional-pro-A-type natriuretic peptide (MRproANP), C-terminal proendothelin 1, copeptin, and midregional-proadrenomedullin.

Methods And Results: We prospectively enrolled unselected patients presenting with syncope to the emergency department (ED) in a diagnostic multicenter study.

Orientation of the Subtalar Joint: Measurement and Reliability Using Weightbearing CT Scans.

Background: Up to 60% of patients with an osteoarthritic ankle joint develop talar tilt with progression of the osteoarthritic process. The configuration of the subtalar joint, in particular the posterior facet, may contribute to the development of this wear pattern. Recently, the subtalar vertical angle (SVA) was used to describe the posterior facet of the subtalar joint in the frontal plane.