Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.

Generation of bispecific antibodies (bsAbs) requires a combination of compatible binders in formats that support desired functionalities. Here, we report that bsAb-matrices can be generated by Format Chain Exchange (FORCE), enabling screening of combinatorial binder/format spaces. Input molecules for generation of bi/multi-valent bsAbs are monospecific entities similar to knob-into-hole half-antibodies, yet with complementary CH3-interface-modulated and affinity-tagged dummy-chains.

Rehabilitation of edentulous jaws with zirconia complete-arch fixed implant-supported prostheses: An up to 4-year retrospective clinical study.

Statement Of Problem: Limited data are available on the clinical outcomes of patients with edentulism treated with zirconia complete-arch fixed implant-supported prostheses (CAFIPs).

Purpose: The primary purpose of this retrospective clinical study was to study the failure rate of dental implants as well as the fracture rate of zirconia CAFIPs. The secondary purpose was to study the survival outcomes of patients with edentulism treated with zirconia CAFIPs as well as the rate of technical complications.

Survival of 2039 complete arch fixed implant-supported zirconia prostheses: A retrospective study.

Statement Of Problem: Presently, data for the survival of 1-piece complete arch fixed implant-supported zirconia prostheses are limited.

Purpose: The purpose of this retrospective study was to evaluate the survival outcomes of 1-piece complete arch fixed implant-supported zirconia prostheses fabricated by a single dental laboratory supporting several clinicians.

Material And Methods: Outcome data were collected over a 5-year period from a large commercial dental laboratory that fabricated 2039 1-piece complete arch fixed implant-supported monolithic zirconia prostheses.