A laboratory study comparing the effect of ridge exposure using tissue punch versus mucoperiosteal flap on the formation of the implant-epithelial junction.

Objective: The objective of the present study was to clarify the influence of the incision design at the time of implant placement on the consolidation of the implanto-epithelial junction.

Study Design: Twelve minipigs were chosen for the study. Four weeks after premolar extraction in the maxilla, 4 BEGO Semados RI implants were inserted in each quadrant.

Analysis of inflammatory periimplant lesions during a 12-week period of undisturbed plaque accumulation--a comparison between flapless and flap surgery in the mini-pig.

This study's aim was to clarify the influence of soft tissue management on the development of periimplant infection. Four weeks after removal of all maxillary premolars in 12 mini-pigs, four BEGO Semados RI implants were inserted in each maxillary quadrant. Employing a split-mouth design, one quadrant was randomized to flapless insertion while the contralateral side was chosen for flap surgery.

Histomorphometric and whole-genome expression analysis of peri-implant soft tissue healing: a comparison of flapless and open surgery.

Purpose: The structure of peri-implant soft tissue that is regenerated after flapless and flap surgery has been shown to differ. However, its underlying mechanisms are relatively unknown. The present study sought to identify differences in the inflammatory cell infiltration and expression of gene transcripts during transmucosal healing between the two approaches with two different implant designs.

Correlation between clinical findings and CT-measured displacement in patients with fractures of the zygomaticomaxillary complex.

Background: This prospective clinical study aimed to analyse the influence of displacement on duration and severity of symptoms of fractures of the zygomaticomaxillary complex.

Methods: 47 patients, who received surgical treatment of zygomaticomaxillary complex fractures at the Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Hospital Jena were examined preoperatively, 1, 3 and 10 days as well as 6 months post-operation for ophthalmologic, occlusal and neurosensory changes.

Results: Preoperatively, periorbital haematoma and ooedema were present in 76.

Comparative analysis of osseointegration of titanium implants with acid-etched surfaces and different biomolecular coatings.

Objectives: An increasing trend toward implantation in complex cases, as well as early loading, is beginning to emerge in dental implantology. Long-term stability of the inserted implants greatly depends on the osseointegration process. Although there are numerous current research efforts aimed at functionalizing implant surfaces, no single factor has proved to be beneficial for osseointegration.

Transgenic overexpression of VEGF164 enhances topical neoangiogenesis without detectable local or systemic side effects.

Various routes of administration have been used for delivering angiogenic genes to ischemic regions. A previous, preliminary study proved the feasibility of in vivo neoangiogenesis stimulation by ex vivo vascular endothelial growth factor (VEGF)-transduced fibroblasts. Taking this into account our aim was to validate therapeutical efficacy of this approach and to investigate potential side effects.

Influence of insertion protocol and implant shoulder design on inflammatory infiltration and gene expression in peri-implant soft tissue during nonsubmerged dental implant healing.

Objective: This study aimed at elucidating the influence of insertion protocol and implant shoulder design on peri-implant soft tissue healing.

Study Design: One month after removal of all maxillary premolars in 12 minipigs, 4 implants were installed in each quadrant. According to implant shoulder design, 3 groups were established: 1) rough, 0.

Multivariate analysis of the influence of patient-, tumor-, and management-related factors on the outcome of surgical therapy for facial basal-cell carcinoma.

Purpose: This retrospective, case-control study aimed at evaluating the influence of patient-, tumor-, and management-related factors on the outcome of surgical therapy for facial basal-cell carcinoma (BCC) employing a multivariate analysis.

Methods: One hundred one patients who underwent ablative surgery for BCC of the face at the Department of Oral and Maxillofacial Surgery/ Plastic Surgery, University Hospital Jena, between April 2005 and January 2009, were analyzed. Patients' charts were screened for anamnestic features as well as management- and follow-up-related details.

Late changes in cutaneous gene expression patterns after adjuvant treatment of oral squamous cell carcinoma (OSCC) by radiation therapy.

Objective: The objective of this study was to investigate radiation-induced late changes in cutaneous gene expression using a microarray platform and quantitative, real-time, reverse-transcriptase polymerase chain reaction (RT-PCR) validation.

Study Design: Paired irradiated and nonirradiated skin biopsies were obtained from 19 patients with a history of oral squamous cell carcinoma (OSCC) treated by surgery and adjuvant radiotherapy at the time of secondary corrective surgery. Topic-defined PIQOR (Parallel Identification and Quantification of RNAs) skin microarrays were used to compare gene expression profiles between control and irradiated skin sample in 8 patients.

Angiogenic gene-modified fibroblasts for induction of localized angiogenesis.

Background: Induction of localized angiogenesis is of particular interest in the field of plastic surgery. Topical application of recombined vascular endothelial growth factor (VEGF) shows only little effect on graft healing. This study describes the establishment of an ex vivo engineered VEGF slow release system based on autogenous fibroblasts.

Combined treatment protocol for temporomandibular joint ankylosis: an observation on a clinical problem.

Various techniques have been defined for the treatment of temporomandibular joint ankylosis. However, in some cases, they are unsuccessful, resulting in continuing pain and limitation in interincisal distance after surgery. This report describes the case of a 32-year-old woman who has been experiencing temporomandibular joint ankylosis for a period of 8 years.

Remission with Imatinib mesylate treatment in a patient with initially unresectable dermatofibrosarcoma protuberans--a case report.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare, malignant dermal mesenchymal neoplasm characterized by a slow, infiltrative growth. These neoplasms have a high tendency to recur locally after surgical excision. However, metastasizing cases are exceedingly rare.

Bone regeneration in osseous defects-application of particulated human and bovine materials.

Objective: Different bone substitute materials are used to manage the challenge of local bone loss subsequent to craniofacial reconstructive surgery. In this animal study we examined the de novo bone formation in bone defects after insertion of Puros Allograft of human origin or Navigraft of bovine origin, and compared the regenerative potential of each material to that of autogenous bone.

Study Design: Using the adult domestic pig as the animal model, we created identical bone defects in the frontal skull and filled them with the different test materials using random assignment.

Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma.

Objective: Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. However, autogenous bone sometimes results in donor site complications. Bone substitutes with platelet-rich plasma (PRP) promote early bone formation with autogenous bone.

Interdisciplinary treatment and ophthalmological findings in Parry-Romberg syndrome.

Parry-Romberg syndrome is a rare pathologic process, characterized by progressive hemifacial atrophy. A case of Parry-Romberg syndrome with ocular involvement is reported. A 27-year-old male patient with Parry-Romberg syndrome was interdisciplinary investigated and treated.

Changes of mineralization of free autogenous bone grafts used for sinus floor elevation.

For augmentations before implant placement in areas of minor bone quantity, autogenous bone is considered the reference to all bone substitutes used alternatively. Autogenous bone transplants originate from various donor areas and can be prepared in different ways before augmentation. They may either be used as block grafts or may be milled to granules that can be used solitarily or in combination with a bone substitute.

Expression of bone matrix proteins during the osseus healing of topical conditioned implants: an experimental study.

Objectives: Osseointegration of implants depends on time and local bone conditions regarding quality and quantity. This led to the bone classification by Lekholm et al. The aim of the present study was to follow the expression of bone matrix proteins during the phase of osseointegration after conditioning of the bone bed by means of immunohistochemistry.

Lack of beneficial effects of platelet-rich plasma on sinus augmentation using a fluorohydroxyapatite or autogenous bone: an explorative study.

Background: Maxillary sinus augmentation is frequently necessary before placement of dental implants in the posterior maxilla. Besides autogenous bone graft, various bone substitutes have been used, with favourable results. Although platelet-rich plasma (PRP) has been used in the field of oral and maxillofacial surgery for years, its beneficial effects on osseous regeneration still remain unclear.

Influence of platelet-rich plasma on a bioglass and autogenous bone in sinus augmentation. An explorative study.

Platelet-rich plasma (PRP) has been introduced to the field of oral and maxillofacial surgery for a decade, but its beneficial effects on maxillary sinus augmentation remain unclear. The aim of this study was to evaluate the short- and long-term effects of PRP on osseointegration following single-stage sinus augmentation in a randomized prospective animal study. The maxillary premolars of 24 minipigs were extracted bilaterally and allowed to heal for 2 months.

Acceleration of de novo bone formation following application of autogenous bone to particulated anorganic bovine material in vivo.

Objective: This prospective animal study examined the de novo bone formation following application of deproteinized bovine bone matrix (DBBM) with or without autogenous bone (AB) to osseous defects.

Study Design: Defects of defined size were created in the frontal skull of domestic pigs and filled with DBBM alone (group A) and DBBM+25%AB (group B). De novo bone formation was analyzed qualitatively and quantitatively at 9 different times (0.

Plasminogen activator inhibitor-I-related regulation of procollagen I (alpha1 and alpha2) by antitransforming growth factor-beta1 treatment during radiation-impaired wound healing.

Purpose: Plasminogen activator inhibitor (PAI)-1 mediates transforming growth factor-beta1 (TGF-beta1)-related signaling by stimulating collagen Type I synthesis in radiation-impaired wound healing. The regulation of alpha(I)-procollagen is contradictory in fibroblasts of different fibrotic lesions. It is not known whether anti-TGF-beta1 treatment specifically inhibits alpha(I)-procollagen synthesis.

Ewing sarcoma of the mandible in a child: interdisciplinary treatment concepts and surgical reconstruction.

Ewing's sarcoma is the second most common primary bone malignancy in childhood and adolescence. We present a standardized interdisciplinary treatment protocol according to the EURO-E.W.

PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation.

This experimental study (domestic pig) examined the bone formation after filling defined defects of the frontal skull with autogenous bone or a deproteinized bovine bone matrix (DBBM) in combination with platelet-rich plasma (PRP). Six groups, both materials with and without PRP in two different concentrations (4.1x and 6.

Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite.

Purpose: This animal study examined the de novo bone formation in bony defects following the insertion of autogenous bone alone versus an injectable nanoparticle hydroxyapatite alone and in combination with 25% autogenous bone. The regenerative potentials of the tested materials were compared with each other.

Materials And Methods: A model with biological similarity to humans with regard to bone regeneration was a prerequisite for the transferability of the results to clinical practice.

Stability of autogenous bone grafts after sinus lift procedures: a comparative study between anterior and posterior aspects of the iliac crest and an intraoral donor site.

Background: Autologous bone is the standard material used for augmentations in oral-maxillofacial surgery. Depending on the origin of the graft, subsequent bone resorption may vary.

Study Design: This prospective study evaluated 57 patients receiving 2-stage sinus floor augmentations.