Publications by authors named "Michael T Porzio"
Article Synopsis
- This study looked at how changes in mitochondria (tiny energy factories inside cells) might cause problems in the nerves of people with diabetes, specifically diabetic peripheral neuropathy (DPN).
- Researchers used special techniques to observe mitochondria in neurons grown in labs and in skin samples from people with diabetes and healthy people.
- The findings showed that in people with DPN, the mitochondria were larger and more numerous, suggesting that these changes might be linked to the nerve damage caused by diabetes.
Purpose: To evaluate the reproducibility of in vivo confocal microscopy for quantitative corneal nerve analysis in different corneal locations.
Methods: Corneal confocal microscopy was performed on 10 healthy participants, and the corneal nerve fiber length, corneal nerve fiber density, corneal nerve branch density, and tortuosity coefficient were measured at 5 predetermined locations for only the right eye. Bland-Altman plots, intraclass correlation coefficient (ICC), and coefficient of variation of all 4 corneal nerve measurements were compared between 2 visits and between readers to assess reproducibility.
Unlabelled: We examined changes in intraepidermal nerve fibers (IENFs) to differentiate patients with diabetic neuropathy (DN) and diabetic neuropathic pain (DN-P) from those with DN without pain (DN-NOP). Punch skin biopsies were collected from the proximal thigh (PT) and distal leg (DL) of normal subjects, patients with type 2 diabetes without evidence of DN (DM), or DN-P and DN-NOP patients. Protein gene product 9.
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